Background: The aim of this study was to identify the differences of intrinsic amygdala, hippocampal, or thalamic networks according to surgical outcomes in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS). Methods: We enrolled 69 pathologically confirmed TLE patients with HS. All patients had pre-operative three-dimensional T1-weighted MRI using a 3.0 T scanner. We obtained the structural volumes of the amygdala nuclei, hippocampal subfields, and thalamic nuclei. Then, we investigated the intrinsic networks based on volumes of these structures using structural covariance and graph theoretical analysis. Results: Of the 69 TLE patients with HS, 21 patients (42.1%) had poor surgical outcomes, whereas 40 patients (57.9%) had good surgical outcomes. The volumes in the amygdala nuclei, hippocampal subfields, and thalamic nuclei were not different according to surgical outcome. In addition, the intrinsic amygdala and hippocampal networks were not different between the patients with poor and good surgical outcomes. However, there was a significant difference in the intrinsic thalamic network in the ipsilateral hemisphere between them. The eccentricity and small-worldness index were significantly increased, whereas the characteristic path length was decreased in the patients with poor surgical outcomes compared to those with good surgical outcomes. Conclusion: We successfully demonstrated significant differences in the intrinsic thalamic network in the ipsilateral hemisphere between TLE patients with HS with poor and good surgical outcomes. This result suggests that the pre-operative intrinsic thalamic network can be related with surgical outcomes in TLE patients with HS.

中文翻译：

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根据手术结果，颞叶癫痫伴海马硬化的内源性丘脑网络。

背景：本研究的目的是根据颞叶癫痫 (TLE) 海马硬化 (HS) 患者的手术结果，确定内在杏仁核、海马或丘脑网络的差异。方法：我们招募了 69 名经病理证实的 TLE 合并 HS 患者。所有患者都使用 3.0 T 扫描仪进行了术前三维 T1 加权 MRI。我们获得了杏仁核、海马亚区和丘脑核的结构体积。然后，我们使用结构协方差和图论分析研究了基于这些结构体积的内在网络。结果：在 69 名患有 HS 的 TLE 患者中，21 名患者 (42.1%) 的手术结果不佳，而 40 名患者 (57.9%) 的手术结果良好。杏仁核、海马亚区、和丘脑核根据手术结果没有不同。此外，内在杏仁核和海马网络在手术结果不佳和良好的患者之间没有差异。然而，它们之间同侧半球的固有丘脑网络存在显着差异。与手术结果良好的患者相比，手术结果差的患者的离心率和小世界指数显着增加，而特征路径长度减少。结论：我们成功地证明了 TLE 患有 HS 的 HS 患者同侧半球内在丘脑网络的显着差异，手术结果不佳和良好。