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A role for mitochondrial DNA in cellular proteostasis
Nature Reviews Genetics ( IF 39.1 ) Pub Date : 2021-09-13 , DOI: 10.1038/s41576-021-00418-9
Caroline Barranco 1
Affiliation  

This molecular phenotyping study shows that common variants in mitochondrial DNA associated with diseases of ageing influence cellular protein homeostasis, and that this link is mediated by circulating levels of N-formylmethionine, the initiating amino acid in mitochondrial protein synthesis.

中文翻译:

线粒体 DNA 在细胞蛋白质稳态中的作用

这项分子表型研究表明,与衰老疾病相关的线粒体 DNA 中的常见变异会影响细胞蛋白质稳态,并且这种联系是由 N-甲酰甲硫氨酸(线粒体蛋白质合成中的起始氨基酸)的循环水平介导的。
更新日期:2021-09-13
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