Placental allopregnanolone affects oligodendrocyte differentiation and myelination in the developing cerebellum. Male mice deprived of allopregnanolone in utero show impaired sociability and communication in later life; their female littermates are unaffected. Allopregnanolone replacement restores normal myelination and behavior.

中文翻译：

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胎盘信号影响小脑发育

胎盘异孕酮影响发育中的小脑中的少突胶质细胞分化和髓鞘形成。在子宫内被剥夺别孕酮的雄性小鼠在以后的生活中表现出社交和交流受损；他们的雌性同窝仔不受影响。别孕酮替代品可恢复正常的髓鞘形成和行为。