All biological systems are composed of molecules of a single chirality. Although many different scenarios can lead to chiral symmetry breaking, the transmission of the absolute configuration of one compound to another one remains challenging. We here demonstrate that during crystallization-induced chiral symmetry breaking by Viedma ripening, a cascade of different and counteracting processes can occur: solid-solution formation and dissolution inhibition favor symmetry breaking towards the same absolute configuration, while enantioselective growth inhibition favors symmetry breaking towards the opposite absolute configuration. These insights offer a new playground for controlling symmetry breaking processes that are of fundamental and practical importance.

中文翻译：

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在手性对称破坏过程中抵消定制添加剂的对映特异性行为：生长抑制与固溶体形成

所有生物系统都由具有单一手性的分子组成。尽管许多不同的情况会导致手性对称性破坏，但将一种化合物的绝对构型传递给另一种化合物仍然具有挑战性。我们在这里证明，在 Viedma 成熟导致结晶诱导的手性对称性破坏期间，可能发生一系列不同的抵消过程：固溶体形成和溶解抑制有利于对称性向相同的绝对构型破坏，而对映选择性生长抑制有利于对称性向着相同的绝对构型破坏相反的绝对配置。这些见解为控制具有基本和实际重要性的对称破坏过程提供了一个新的领域。