Using 2-isopropyl-2-oxazine to explore the effect of monomer distribution and polymer architecture on the thermoresponsive behavior of copolymers,Journal of Polymer Science

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Using 2-isopropyl-2-oxazine to explore the effect of monomer distribution and polymer architecture on the thermoresponsive behavior of copolymers
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2021-09-13 , DOI: 10.1002/pol.20210551
Nicole M. Warne ₁ , John R. Finnegan ₁ , Orlagh M. Feeney ₁ , Kristian Kempe _{1,

2}

Affiliation

Poly(cyclic imino ether)s (PCIE) have emerged as a highly promising class of polymer for use in biomedical applications with their value being derived from their excellent biocompatibility, diverse chemistry, and tunable hydrophilicity. Here, we investigate the properties of poly(2-isopropyl-2-oxazine) (PiPrOz), a relatively unexplored PCIE, determining it to have a cloud point temperature (T_cp) below physiological temperature, not to crystallize from bulk or in solution, and to be highly biocompatible. Furthermore, a series of copolymers consisting of iPrOz and 2-methyl-2-oxazine (MeOz) was investigated with regard to the effect of monomer distribution and polymer architecture on thermoresponsive properties. To this end, linear block and statistical co-poly(2-oxazine)s (co-POz), along with three comb-shaped POz with block or statistical POz side chains were prepared. Each of the five polymers showed distinct thermoresponsive behavior, with the linear block co-POz undergoing micelle formation and the other polymers macroscopic phase-separation at different T_cps. The variety observed in response to heating clearly highlights the importance of monomer sequence and polymer architecture when designing thermoresponsive polymers. We anticipate that our findings will prove useful to polymer chemists seeking to prepare novel thermoresponsive biomaterials.

中文翻译：

使用 2-isopropyl-2-oxazine 探索单体分布和聚合物结构对共聚物热响应行为的影响

聚（环状亚氨基醚）（PCIE）已成为一类极具前景的聚合物，可用于生物医学应用，其价值源于其优异的生物相容性、多样化的化学性质和可调节的亲水性。在这里，我们研究了聚（2-异丙基-2-恶嗪）（PiPrOz）的特性，这是一种相对未开发的 PCIE，确定它具有浊点温度（T _cp) 低于生理温度，不会从本体或溶液中结晶，并且具有高度的生物相容性。此外，研究了一系列由 iPrOz 和 2-甲基-2-恶嗪 (MeOz) 组成的共聚物，研究了单体分布和聚合物结构对热响应性能的影响。为此，制备了线性嵌段和统计共聚（2-恶嗪）（co-POz），以及三个具有嵌段或统计 POz 侧链的梳状 POz。五种聚合物中的每一种都表现出不同的热响应行为，线性嵌段 co-POz 进行胶束形成，而其他聚合物在不同的T _{cp 下}宏观相分离s。在加热响应中观察到的变化清楚地突出了单体序列和聚合物结构在设计热敏聚合物时的重要性。我们预计我们的发现将对寻求制备新型热响应生物材料的聚合物化学家有用。

更新日期：2021-11-15

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