Chronic pruritus associated with systemic diseases in the pediatric population has been infrequently addressed in the literature. This review focuses on chronic pruritus presenting without cutaneous manifestations. Common systemic etiologies include diseases with hepatic, renal, and hematologic origins. This encompasses several congenital liver disorders, end-stage renal disease (ESRD), and lymphoproliferative disorders such as Hodgkin's lymphoma. In this paper, an expert panel describes the clinical characteristics, pathophysiology, and therapeutic treatment ladders for chronic pruritus associated with the aforementioned systemic etiologies. Novel therapies are also reviewed. Our aim is to shed light on this unexplored area of pediatric dermatology and instigate further research.

中文翻译：

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儿科人群非皮肤病慢性瘙痒的全身性原因及其管理：一个未探索的领域

与儿科系统性疾病相关的慢性瘙痒症在文献中很少提及。本综述重点介绍无皮肤表现的慢性瘙痒。常见的全身性病因包括肝脏、肾脏和血液系统疾病。这包括几种先天性肝病、终末期肾病 (ESRD) 和淋巴增生性疾病，如霍奇金淋巴瘤。在本文中，专家小组描述了与上述全身性病因相关的慢性瘙痒的临床特征、病理生理学和治疗阶梯。还审查了新疗法。我们的目标是阐明这一尚未探索的儿科皮肤病领域，并推动进一步的研究。