Introduction The purpose of this study was to characterize using MRI the effects of a 10-week supervised exercise program on lower extremity skeletal muscle composition, nerve microarchitecture, and metabolic function in individuals with diabetic peripheral neuropathy (DPN). Research design and methods Twenty participants with DPN completed a longitudinal trial consisting of a 30-day control period, during which subjects made no change to their lifestyle, followed by a 10-week intervention program that included three supervised aerobic and resistance exercise sessions per week targeting the upper and lower extremities. The participants’ midcalves were scanned with multinuclear MRI two times prior to intervention (baseline1 and baseline2) and once following intervention to measure relaxation times (T1, T1ρ, and T2), phosphocreatine recovery, fat fraction, and diffusion parameters. Results There were no changes between baseline1 and baseline2 MRI metrics (p>0.2). Significant changes (p<0.05) between baseline2 and postintervention MRI metrics were: gastrocnemius medialis (GM) T1 –2.3%±3.0% and soleus T2 –3.2%±3.1%. Trends toward significant changes (0.050.3) and tibial nerve fractional anisotropy (p>0.6) and apparent diffusion coefficient (p>0.4). Conclusions The 10-week supervised exercise intervention program successfully reduced adiposity and altered resting tissue properties in the lower leg in DPN. Gastrocnemius mitochondrial oxidative capacity and tibial nerve microarchitecture changes were not observed, either due to lack of response to therapy or to lack of measurement sensitivity. Data are available upon reasonable request. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. No applicable resources were generated or analyzed during the current study.

中文翻译：

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糖尿病周围神经病变患者进行 10 周监督运动干预后的下肢 MRI

简介 本研究的目的是使用 MRI 表征 10 周监督锻炼计划对糖尿病周围神经病变 (DPN) 患者下肢骨骼肌成分、神经微结构和代谢功能的影响。研究设计和方法 20 名 DPN 参与者完成了一项纵向试验，该试验包括 30 天的控制期，在此期间受试者没有改变他们的生活方式，随后是为期 10 周的干预计划，其中包括每周 3 次有监督的有氧运动和阻力运动针对上肢和下肢。在干预前两次（基线 1 和基线 2）以及干预后一次用多核 MRI 扫描参与者的小腿中部以测量松弛时间（T1、T1ρ 和 T2）、磷酸肌酸恢复、脂肪分数和扩散参数。结果 baseline1 和 baseline2 MRI 指标之间没有变化 (p>0.2)。基线 2 和干预后 MRI 指标之间的显着变化 (p<0.05) 是：腓肠肌内侧肌 (GM) T1 –2.3%±3.0% 和比目鱼肌 T2 –3.2%±3.1%。显着变化的趋势 (0.050.3) 和胫神经分数各向异性 (p>0.6) 和表观扩散系数 (p>0.4)。结论 为期 10 周的监督运动干预计划成功地减少了 DPN 小腿的肥胖并改变了静息组织特性。由于对治疗缺乏反应或缺乏测量敏感性，未观察到腓肠肌线粒体氧化能力和胫神经微结构变化。可根据合理要求提供数据。在当前研究期间生成和/或分析的数据集可根据合理要求从相应的作者处获得。在当前研究期间没有生成或分析适用的资源。