Background The highly contagious SARS-CoV-2 is mainly transmitted by respiratory droplets and aerosols. Consequently, people are required to wear masks and maintain a social distance to avoid spreading of the virus. Despite the success of the commercially available vaccines, the virus is still uncontained globally. Given the tropism of SARS-CoV-2, a mucosal immune reaction would help to reduce viral shedding and transmission locally. Only seven out of hundreds of ongoing clinical trials are testing the intranasal delivery of COVID-19 vaccines.

中文翻译：

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针对 COVID-19 的基于 VLP 的疫苗的鼻内给药诱导针对 SARS-CoV-2 和关注变体的中和抗体

背景具有高度传染性的 SARS-CoV-2 主要通过呼吸道飞沫和气溶胶传播。因此，人们必须戴口罩并保持社交距离，以避免病毒传播。尽管市售疫苗取得了成功，但该病毒在全球范围内仍未得到控制。鉴于 SARS-CoV-2 的趋向性，粘膜免疫反应将有助于减少病毒的局部脱落和传播。在数百项正在进行的临床试验中，只有七项正在测试 COVID-19 疫苗的鼻内给药。