Millions of symbiotic and pathogenic microorganisms known as microbiota colonize the host body. The microbiome plays an important role in human health and colonizes hundreds of different species of multicellular organisms so that they are introduced as the metaorganisms. Changes in the microbial population of the gut microbiome may cause resistance to pathogenic bacteria-induced infection. Understanding the principles of Host-Microbiota Interactions (HMIs) is important because it clarifies our insight towards the mechanisms of infections established in the host. Interactions between the host and the microbiota help answer the question of how a microorganism can contribute to the health or disease of the host. Microbiota can increase host resistance to colonization of pathogenic species. Studying the HMIs network can in several ways delineate the pathogenic mechanisms of pathogens and thereby help to increase useful and novel therapeutic pathways. For example, the potentially unique microbial effects that target the distinct host or interfere with the endogenous host interactions can be identified. In addition, the way mutations in essential proteins in the host and/or in the microbes can influence the interactions between them may be determined. Furthermore, HMIs help in identifying host cell regulatory modules.

数百万被称为微生物群的共生微生物和病原微生物在宿主体内定殖。微生物组在人类健康中起着重要作用，并在数百种不同种类的多细胞生物中定殖，因此它们被引入作为元生物。肠道微生物群中微生物种群的变化可能会导致对病原菌诱导的感染产生抵抗力。了解宿主-微生物群相互作用 (HMI) 的原理很重要，因为它阐明了我们对宿主中建立的感染机制的见解。宿主和微生物群之间的相互作用有助于回答微生物如何对宿主的健康或疾病做出贡献的问题。微生物群可以增加宿主对病原物种定殖的抵抗力。研究 HMIs 网络可以通过多种方式描绘病原体的致病机制，从而有助于增加有用和新颖的治疗途径。例如，可以识别针对不同宿主或干扰内源宿主相互作用的潜在独特微生物效应。此外，可以确定宿主和/或微生物中必需蛋白质的突变可以影响它们之间相互作用的方式。此外，HMI 有助于识别宿主细胞调节模块。可以确定宿主和/或微生物中必需蛋白质的突变可以影响它们之间相互作用的方式。此外，HMI 有助于识别宿主细胞调节模块。可以确定宿主和/或微生物中必需蛋白质的突变可以影响它们之间相互作用的方式。此外，HMI 有助于识别宿主细胞调节模块。