Implant-related bacterial infection is a serious complication, which even causes implant failure. Silver (Ag) nanoparticles are broadly used antibacterial agents due to their excellent antibacterial ability and broad-spectrum bactericidal property. However, the significance of burst release cannot be entirely ignored. In this study, Ag doped mesoporous bioactive glasses (Ag-MBG) nanospheres were synthesized using modified Stöber method, then incorporated into poly L-lactic acid (PLLA) matrix to prepare the composite scaffolds via selective laser sintering (SLS) technology. Herein, Mesoporous bioactive glasses (MBG) sol had many negatively-charged silicon hydroxyl groups, which could adsorb positively-charged Ag ions by electrostatic interaction and eventually form Si-O-Ag bonds into MBG. Moreover, MBG promoted osteoblast colonization due to its continuous release of Si ions. The results showed the Ag-MBG/PLLA scaffold could sustainedly release Ag ions for 28 days, and exhibited significantly antibacterial ability against Escherichia coli, its bacterial inhibition rate was over 80%. In addition, the composite scaffold also showed good cytocompatibility. It may be concluded that the prepared Ag-MBG/PLLA scaffold has great potential to repair implant-associated bone infection.

种植体相关细菌感染是一种严重的并发症，甚至会导致种植体失败。银（Ag）纳米粒子由于其优异的抗菌能力和广谱杀菌特性而被广泛使用。但是，突发释放的重要性也不能完全忽视。在这项研究中，使用改进的 Stöber 方法合成了掺银的介孔生物活性玻璃 (Ag-MBG) 纳米球，然后将其掺入聚 L-乳酸 (PLLA) 基质中，通过选择性激光烧结 (SLS) 技术制备复合支架。在此，介孔生物活性玻璃（MBG）溶胶具有许多带负电荷的硅羟基，可以通过静电相互作用吸附带正电荷的Ag离子，最终形成Si-O-Ag键形成MBG。而且，MBG 由于其持续释放 Si 离子而促进成骨细胞定植。结果表明，Ag-MBG/PLLA支架可以持续释放Ag离子28天，并表现出显着的抗菌能力。大肠杆菌，其抑菌率达80%以上。此外，复合支架还表现出良好的细胞相容性。可以得出结论，制备的 Ag-MBG/PLLA 支架具有修复种植体相关骨感染的巨大潜力。