Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study,eLife

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Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study
eLife ( IF 6.4 ) Pub Date : 2021-09-13 , DOI: 10.7554/elife.68671
Jiahui Si _{1,

2} , Songchun Yang ₁ , Dianjianyi Sun ₁ , Canqing Yu ₁ , Yu Guo ₃ , Yifei Lin ₄ , Iona Y Millwood _{5,

6} , Robin G Walters _{5,

6} , Ling Yang _{5,

6} , Yiping Chen _{5,

6} , Huaidong Du _{5,

6} , Yujie Hua ₇ , Jingchao Liu ₈ , Junshi Chen ₉ , Zhengming Chen ₆ , Wei Chen ₁₀ , Jun Lv _{1,

11,

12} , Liming Liang ₂ , Liming Li ₁ ,

Affiliation

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States.
Chinese Academy of Medical Sciences, Beijing, China.
Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom.
Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
NCDs Prevention and Control Department, Suzhou CDC, Jiangsu, China.
NCDs Prevention and Control Department, Wuzhong CDC, Jiangsu, China.
China National Center for Food Safety Risk Assessment, Beijing, China.
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, United States.
Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, China.
Peking University Institute of Environmental Medicine, Beijing, China.

Background: Identifying environmentally responsive genetic loci where DNA methylation is associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic targets for CHD. We conducted the first prospective epigenome-wide analysis of DNA methylation in relation to incident CHD in the Asian population.

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