Magnetic hyperthermia has been studied for the past two decades in cancer treatments as the local heat generated by magnetic nanoparticles under applied alternating magnetic fields is sufficient to kill cancer cells. More recently, it has been explored for controlling biological signaling through heat-sensitive transmembrane channels. It is of great interest to produce magnetic nanoparticles with high heat transducing efficiency to minimize potential off-target heating effects. Here, we describe shape anisotropy and particle hybridization as possible routes to augment magnetic hyperthermia in ferrite nanoparticles. Zinc substituted magnetite core and core-shell cubic nanoparticles with different sizes were synthetized. It was found that nanoparticles shape and composition are altered from cubic to flower-like, and to a more franklinite rich phase as size increased. Hybridization with a cobalt shell allowed to enhance nanoparticle magnetic coercivity and specific power loss. The optimized core-shell nanoparticles were tested to induce cellular activity in hippocampal neurons.

中文翻译：

---

通过形状各向异性和表面杂化增强铁氧体纳米粒子中的磁热疗

磁热疗在过去的二十年中一直在癌症治疗中得到研究，因为磁性纳米粒子在施加的交变磁场下产生的局部热量足以杀死癌细胞。最近，它已被探索通过热敏跨膜通道控制生物信号。生产具有高热转换效率的磁性纳米粒子以最大限度地减少潜在的脱靶热效应是非常有趣的。在这里，我们将形状各向异性和粒子杂化描述为增强铁氧体纳米粒子中磁热疗的可能途径。合成了不同尺寸的锌取代磁铁矿核和核壳立方纳米粒子。发现纳米颗粒的形状和成分从立方体变为花状，并且随着尺寸的增加变成更富含富兰克林石的相。与钴壳的杂交允许增强纳米粒子磁矫顽力和比功率损失。测试优化的核壳纳米粒子以诱导海马神经元的细胞活动。