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Biocompatible and Biodegradable Neuromorphic Device Based on Hyaluronic Acid for Implantable Bioelectronics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-09-12 , DOI: 10.1002/adfm.202107074 Jin Hyeok Lee 1 , You Seung Rim 2 , Won Kyung Min 1 , Kyungho Park 1 , Hyung Tae Kim 1 , Gyuho Hwang 3 , Jaewhan Song 3 , Hyun Jae Kim 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-09-12 , DOI: 10.1002/adfm.202107074 Jin Hyeok Lee 1 , You Seung Rim 2 , Won Kyung Min 1 , Kyungho Park 1 , Hyung Tae Kim 1 , Gyuho Hwang 3 , Jaewhan Song 3 , Hyun Jae Kim 1
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Neurodegenerative disorders are challenging issues for initial diagnosis and cure. False signals from neurons that make up the brain must be corrected. To treat neurodegenerative diseases, neuromorphic devices are inserted into the body and connected to nerves. However, there are major concerns regarding implanting these devices into living bodies, that is, toxicity caused by the materials and the need for an additional operation to remove the device after treatment. In this research, a neuromorphic device is fabricated based on hyaluronic acid (HA), which is biocompatible and biodegradable, that meets the requirements for implantable bioelectronics. The fabricated device have a paired-pulse facilitation index of ≈121.00% and short term-to-long term memory transition behavior that resembled human learning-experience behavior. It is confirmed that the synaptic behavior mechanism of the device is due to an Mg oxide layer formed at the Mg/HA interface. Biodegradability and cell cytotoxicity tests confirmed the suitability of HA-based neuromorphic devices as implantable bioelectronics. Based on the results, it is believed that such implantable devices will lead to better healthcare.
中文翻译：
基于透明质酸的用于植入式生物电子学的生物相容性和可生物降解的神经形态装置
神经退行性疾病是初步诊断和治愈的挑战性问题。必须纠正来自构成大脑的神经元的错误信号。为了治疗神经退行性疾病，神经形态装置被插入体内并连接到神经。然而，将这些装置植入活体存在主要问题，即材料引起的毒性以及治疗后需要额外操作以移除装置。在这项研究中，基于透明质酸 (HA) 制造了一种神经形态装置，它具有生物相容性和可生物降解性，符合可植入生物电子学的要求。制造的设备有成对的脉冲促进指数≤121.00%和类似于人类学习体验行为的短期到长期记忆转换行为。证实该器件的突触行为机制是由于在 Mg/HA 界面处形成的氧化镁层。生物降解性和细胞毒性测试证实了基于 HA 的神经形态设备作为可植入生物电子设备的适用性。根据结果，相信这种可植入设备将带来更好的医疗保健。
更新日期：2021-09-12
中文翻译：
基于透明质酸的用于植入式生物电子学的生物相容性和可生物降解的神经形态装置
神经退行性疾病是初步诊断和治愈的挑战性问题。必须纠正来自构成大脑的神经元的错误信号。为了治疗神经退行性疾病，神经形态装置被插入体内并连接到神经。然而，将这些装置植入活体存在主要问题，即材料引起的毒性以及治疗后需要额外操作以移除装置。在这项研究中，基于透明质酸 (HA) 制造了一种神经形态装置，它具有生物相容性和可生物降解性，符合可植入生物电子学的要求。制造的设备有成对的脉冲促进指数≤121.00%和类似于人类学习体验行为的短期到长期记忆转换行为。证实该器件的突触行为机制是由于在 Mg/HA 界面处形成的氧化镁层。生物降解性和细胞毒性测试证实了基于 HA 的神经形态设备作为可植入生物电子设备的适用性。根据结果，相信这种可植入设备将带来更好的医疗保健。
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