Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo,Advanced Functional Materials

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Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-09-12 , DOI: 10.1002/adfm.202105989
Samuel Pearson ₁ , Jun Feng _{1,

2} , Aránzazu del Campo _{1,

2}

Affiliation

Photoresponsive biomaterials are experiencing a transition from in vitro models to in vivo demonstrations that point toward clinical translation. Dynamic hydrogels for cell encapsulation, light-responsive carriers for controlled drug delivery, and nanomaterials containing photosensitizers for photodynamic therapy are relevant examples. Nonetheless, the step to the clinic largely depends on their combination with technologies to bring light into the body. This review highlights the challenge of photoactivation in vivo, and presents strategies for light management that can be adopted for this purpose. The authors’ focus is on technologies that are materials-driven, particularly upconversion nanoparticles that assist in “direct path” light delivery through tissue, and optical waveguides that “clear the path” between external light source and in vivo target. The authors’ intention is to assist the photoresponsive biomaterials community transition toward medical technologies by presenting light delivery concepts that can be integrated with the photoresponsive targets. The authors also aim to stimulate further innovation in materials-based light delivery platforms by highlighting needs and opportunities for in vivo photoactivation of biomaterials.

中文翻译：

照亮道路：在体内激活光响应生物材料的光传递策略

光响应生物材料正在经历从体外模型到指向临床转化的体内演示的转变。用于细胞封装的动态水凝胶、用于受控药物递送的光响应载体以及用于光动力疗法的含有光敏剂的纳米材料都是相关的例子。尽管如此，进入诊所的步骤在很大程度上取决于它们与将光线引入体内的技术的结合。这篇综述强调了体内光活化的挑战，并提出了可用于此目的的光管理策略。作者的重点是材料驱动的技术，特别是有助于“直接路径”光通过组织传递的上转换纳米粒子，以及在外部光源和体内目标之间“清除路径”的光波导。作者的目的是通过提出可以与光响应目标集成的光传输概念来帮助光响应生物材料社区向医疗技术过渡。作者还旨在通过强调生物材料体内光活化的需求和机会来刺激基于材料的光传输平台的进一步创新。

更新日期：2021-09-12

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