Intraluminal vesicles accumulate within the endosomal lumen before lysosomal delivery or extracellular release. A new study reports the development of an elegant assay showing that these vesicles can escape from the endosomal lumen by ‘back-fusion’ or ‘retrofusion’ with the endosomal limiting membrane.

中文翻译：

---

膜运输：逆流作为内体的逃逸路线

在溶酶体递送或细胞外释放之前，腔内囊泡在内体腔内积聚。一项新的研究报告了一种优雅的分析方法的发展，表明这些囊泡可以通过与内体限制膜的“反向融合”或“逆向融合”从内体腔中逸出。