Phytomedicine ( IF 6.7 ) Pub Date : 2021-09-13 , DOI: 10.1016/j.phymed.2021.153736 Haoyang Zou 1 , Haiqing Ye 1 , Rajamanikkam Kamaraj 2 , Tiehua Zhang 1 , Jie Zhang 1 , Petr Pavek 2
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Background
Quercetin is a natural flavonoid, which widely exists in nature, such as tea, coffee, apples, and onions. Numerous studies have showed that quercetin has multiple biological activities such as anti-oxidation, anti-inflammatory, and anti-aging. Hence, quercetin has a significant therapeutic effect on cancers, obesity, diabetes, and other diseases. In the past decades, a large number of studies have shown that quercetin combined with other agents can significantly improve the overall therapeutic effect, compared to single use.
Purpose
This work reviews the pharmacological activities of quercetin and its derivatives. In addition, this work also summarizes both in vivo and in vitro experimental evidence for the synergistic effect of quercetin against cancers and metabolic diseases.
Methods
An extensive systematic search for pharmacological activities and synergistic effect of quercetin was performed considering all the relevant literatures published until August 2021 through the databases including NCBI PubMed, Scopus, Web of Science, and Google Scholar. The relevant literatures were extracted from the databases with following keyword combinations: "pharmacological activities" OR "biological activities" OR "synergistic effect" OR "combined" OR "combination" AND "quercetin" as well as free-text words.
Results
Quercetin and its derivatives possess multiple pharmacological activities including anti-cancer, anti-oxidant, anti-inflammatory, anti-cardiovascular, anti-aging, and neuroprotective activities. In addition, the synergistic effect of quercetin with small molecule agents against cancers and metabolic diseases has also been confirmed.
Conclusion
Quercetin cooperates with agents to improve the therapeutic effect by regulating signal molecules and blocking cell cycle. Synergistic therapy can reduce the dose of agents and avoid the possible toxic and side effects in the treatment process. Although quercetin treatment has some potential side effects, it is safe under the expected use conditions. Hence, quercetin has application value and potential strength as a clinical drug. Furthermore, quercetin, as the main effective therapeutic ingredient in traditional Chinese medicine, may effectively treat and prevent coronavirus disease 2019 (COVID-19).
中文翻译：
槲皮素与小分子药物的药理活性及协同作用综述
背景
槲皮素是一种天然黄酮类化合物，广泛存在于自然界，如茶、咖啡、苹果、洋葱等。大量研究表明，槲皮素具有抗氧化、抗炎、抗衰老等多种生物活性。因此，槲皮素对癌症、肥胖症、糖尿病等疾病具有显着的治疗作用。在过去的几十年中，大量研究表明，槲皮素与其他药物联合使用，与单独使用相比，可以显着提高整体治疗效果。
目的
这项工作回顾了槲皮素及其衍生物的药理活性。此外，这项工作还总结了槲皮素对癌症和代谢疾病的协同作用的体内和体外实验证据。
方法
考虑到 2021 年 8 月之前通过 NCBI PubMed、Scopus、Web of Science 和 Google Scholar 等数据库发表的所有相关文献，对槲皮素的药理活性和协同作用进行了广泛的系统搜索。从数据库中提取相关文献，关键词组合如下：“药理活性” OR “生物活性” OR “协同作用” OR “组合” OR “组合” AND “槲皮素”以及自由文本词。
结果
槲皮素及其衍生物具有多种药理活性，包括抗癌、抗氧化、抗炎、抗心血管、抗衰老和神经保护活性。此外，槲皮素与小分子药物对癌症和代谢性疾病的协同作用也得到证实。
结论
槲皮素与药剂配合，通过调节信号分子和阻断细胞周期来提高治疗效果。协同治疗可减少药剂用量，避免治疗过程中可能出现的毒副作用。虽然槲皮素治疗有一些潜在的副作用，但在预期的使用条件下是安全的。因此，槲皮素作为临床药物具有应用价值和潜力。此外，槲皮素作为中药的主要有效治疗成分，可有效治疗和预防2019冠状病毒病（COVID-19）。
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