Aqueous-Based Silica Nanoparticles as Carriers for Catalytically Active Biomacromolecules,ACS Applied Nano Materials

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Aqueous-Based Silica Nanoparticles as Carriers for Catalytically Active Biomacromolecules
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2021-09-13 , DOI: 10.1021/acsanm.1c01656
Guoning Chen ₁ , Qianqian Hu ₁ , Florian Schulz ₂ , Wolfgang J. Parak ₂ , Lu Wang ₁ , Xia Cui ₁ , Ke Yang ₁ , Zhimin Luo ₁ , Aiguo Zeng ₁ , Qiang Fu _{1,

3}

Affiliation

Silica nanoparticles have emerged as excellent hosting matrices for the immobilization of biomacromolecules due to good biocompatibility, chemical stability, low toxicity, and facile controllability. However, most of the traditional synthesis protocols for silica nanoparticles are based on hydrolysis and condensation of alkoxysilane in aqueous alcohol solutions in the presence of ammonia as a catalyst. Such conditions are too harsh for encapsulation of certain biomacromolecules. Herein, a one-step method for the synthesis of silica nanoparticles with encapsulated biomacromolecules in an aqueous solution without alcohol and catalyst is proposed. To demonstrate the feasibility of this strategy, six different kinds of biomacromolecules were encapsulated in the silica nanoparticles as model systems. The biomacromolecules encapsulated in the silica nanoparticles still preserved high bioactivity. The composites showed an excellent reusability and a good protective effect against various extreme environments. This study demonstrates how silica nanoparticles can be prepared for biomacromolecule immobilization without any alcohol and catalyst and thus offers improved encapsulation.

中文翻译：

水基二氧化硅纳米粒子作为催化活性生物大分子的载体

由于良好的生物相容性、化学稳定性、低毒性和易控制性，二氧化硅纳米粒子已成为用于固定生物大分子的优良宿主基质。然而，大多数二氧化硅纳米粒子的传统合成方案都是基于在氨作为催化剂的情况下，烷氧基硅烷在醇水溶液中的水解和缩合。这样的条件对于某些生物大分子的包封来说过于苛刻。在此，提出了一种在不含醇和催化剂的水溶液中一步法合成具有包封生物大分子的二氧化硅纳米粒子的方法。为了证明该策略的可行性，将六种不同的生物大分子封装在二氧化硅纳米粒子中作为模型系统。封装在二氧化硅纳米颗粒中的生物大分子仍然保持高生物活性。该复合材料显示出优异的重复使用性和对各种极端环境的良好保护作用。这项研究展示了如何在没有任何酒精和催化剂的情况下制备二氧化硅纳米粒子用于生物大分子固定，从而提供更好的封装。

更新日期：2021-09-24

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