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Multi-color stimulated Raman scattering with a frame-to-frame wavelength-tunable fiber-based light source
Biomedical Optics Express ( IF 2.9 ) Pub Date : 2021-09-13 , DOI: 10.1364/boe.436299
Thomas Würthwein 1 , Kristin Wallmeier 1 , Maximilian Brinkmann 2 , Tim Hellwig 2 , Niklas M Lüpken 1 , Nick S Lemberger 1 , Carsten Fallnich 1, 3, 4
Affiliation  

We present multi-color imaging by stimulated Raman scattering (SRS) enabled by an ultrafast fiber-based light source with integrated amplitude modulation and frame-to-frame wavelength tuning. With a relative intensity noise level of -153.7 dBc/Hz at 20.25 MHz the light source is well suited for SRS imaging and outperforms other fiber-based light source concepts for SRS imaging. The light source is tunable in under 5 ms per arbitrary wavelength step between 700 cm−1 and 3200 cm−1, which allows for addressing Raman resonances from the fingerprint to the CH-stretch region. Moreover, the compact and environmentally stable system is predestined for fast multi-color assessments of medical or rapidly evolving samples with high chemical specificity, paving the way for diagnostics and sensing outside of specialized laser laboratories.

中文翻译:

多色受激拉曼散射与帧到帧波长可调的光纤光源

我们通过具有集成调幅和帧到帧波长调谐的超快光纤光源实现受激拉曼散射 (SRS) 提供多色成像。该光源在 20.25 MHz 时的相对强度噪声水平为 -153.7 dBc/Hz,非常适合 SRS 成像,并且优于其他用于 SRS 成像的基于光纤的光源概念。光源可在 700 cm -1和 3200 cm -1之间的任意波长步长内在 5 ms 以下进行调谐,这允许解决从指纹到 CH 拉伸区域的拉曼共振。此外,紧凑且环境稳定的系统注定要对具有高化学特异性的医学或快速发展的样品进行快速多色评估,为专业激光实验室之外的诊断和传感铺平了道路。
更新日期:2021-10-01
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