Frontiers in Endocrinology ( IF 3.9 ) Pub Date : 2021-09-13 , DOI: 10.3389/fendo.2021.705264 Mingze Du 1 , Junwei Zhang 1 , Zhen Li 1 , Xinmi Liu 1 , Jing Li 1 , Wenxia Liu 1 , Yichun Guan 1
To compare the cumulative live birth rate (CLBR) of the progestin-primed ovarian stimulation (PPOS) protocol with that of the flexible GnRH antagonist protocol in patients with poor prognosis diagnosed per the POSEIDON criteria.
This was a retrospective cohort study. Low-prognosis women who underwent IVF/ICSI at the Reproductive Center of Third Affiliated Hospital of Zhengzhou University between January 2016 and January 2019 were included according to the POSEIDON criteria. The CLBR was the primary outcome of interest. The secondary outcome measures were the numbers of oocytes retrieved, 2PN embryos, available embryos and time to live birth.
A total of 1329 women met the POSEIDON criteria for analysis. For POSEIDON group 1, the dosage of gonadotropin (Gn) was higher in the PPOS group than in the GnRH antagonist group (2757.3 ± 863.1
For low-prognosis patients diagnosed per the POSEIDON criteria, the CLBR of PPOS protocols is comparable to that of GnRH antagonist protocols. In the POSEIDON group 1 population, the GnRH antagonist protocols resulted in a shorter time to live birth.
中文翻译:
低预后患者孕激素促排卵和灵活 GnRH 拮抗剂方案累积活产率的比较
在根据 POSEIDON 标准诊断为预后不良的患者中,比较孕激素促排卵 (PPOS) 方案与灵活 GnRH 拮抗剂方案的累积活产率 (CLBR)。
这是一项回顾性队列研究。根据 POSEIDON 标准,纳入 2016 年 1 月至 2019 年 1 月期间在郑州大学第三附属医院生殖中心接受 IVF/ICSI 的低预后女性。CLBR 是感兴趣的主要结果。次要结果指标是取回的卵母细胞数量、2PN 胚胎、可用胚胎和活产时间。
共有 1329 名女性符合 POSEIDON 分析标准。对于 POSEIDON 组 1,PPOS 组的促性腺激素 (Gn) 剂量高于 GnRH 拮抗剂组 (2757.3 ± 863.1
对于根据 POSEIDON 标准诊断的低预后患者,PPOS 方案的 CLBR 与 GnRH 拮抗剂方案的 CLBR 相当。在 POSEIDON 第 1 组人群中,GnRH 拮抗剂方案可缩短活产时间。