Electrospinning is a promising method to fabricate bioengineered scaffolds, thanks to utilizing various types of biopolymers, flexible structures, and also the diversity of output properties. Mechanical properties are one of the major components of scaffold design to fabricate an efficacious artificial substitute for the natural extracellular matrix. Additionally, fiber orientations, as one of the scaffold structural parameters, could play a crucial role in the application of fabricated fibrous scaffolds. In this study, gelatin was used as a highly biocompatible polymer in blend with cellulose acetate (CA), a polysaccharide, to enhance the achievable range of mechanical characteristics to fabricated fibrous electrospun scaffolds. By altering input variables, such as polymers concentration, weight ratio, and mandrel rotation speed, scaffolds with various mechanical and morphological properties could be achieved. As expected, the electrospun scaffold with a higher mandrel rotation speed shows higher fiber alignment. A wide range of mechanical properties were gained through different values of polymer ratio and total concentration. A general improvement in mechanical strength was observed by increasing the concentration and CA content in the solution, but contradictory effects, such as high viscosity in more concentrated solutions, influenced the mechanical characteristics as well. A response surface method was applied on experimental results in order to describe a continuous variation of Young’s modulus, yield stress, and strain at rupture. A full quadratic version of equations with the 95% confidence level was applied for the response modeling. This model would be an aid for engineers to adjust mandrel rotation speed, solution concentration, and gelatin/CA ratio to achieve desired mechanical and structural properties.

由于利用了各种类型的生物聚合物、柔性结构以及输出特性的多样性，静电纺丝是一种有前景的制造生物工程支架的方法。机械性能是支架设计的主要组成部分之一，用于制造天然细胞外基质的有效人工替代品。此外，纤维取向作为支架结构参数之一，在制造纤维支架的应用中可以发挥至关重要的作用。在这项研究中，明胶被用作一种高度生物相容性的聚合物，与一种多糖醋酸纤维素（CA）混合，以增强制造的纤维电纺支架的机械特性的可实现范围。通过改变输入变量，例如聚合物浓度、重量比和心轴旋转速度，可以获得具有各种机械和形态特性的支架。正如预期的那样，具有较高心轴旋转速度的电纺支架显示出较高的纤维排列。通过不同的聚合物比例和总浓度值可以获得广泛的机械性能。通过增加溶液中的浓度和 CA 含量，可以观察到机械强度的总体改善，但矛盾的效果（例如更浓缩的溶液中的高粘度）也会影响机械特性。对实验结果应用响应面法，以描述杨氏模量、屈服应力和断裂应变的连续变化。响应建模采用了具有 95% 置信水平的完整二次方程版本。 该模型将有助于工程师调整心轴旋转速度、溶液浓度和明胶/CA 比例，以实现所需的机械和结构性能。