To accelerate serious skin burn wound healing in a convenient manner, an interpenetrating network of hydrogel consisting of gellan gum and polyacrylamide was synthesized by chemical crosslinking and Mg²⁺ ion immersion techniques. The prepared Mg²⁺@PAM/GG hydrogel was characterized by morphology, water vapor loss, swelling ratio, rheological properties, tensile mechanical, biocompatibility, and flow cytometry study. The results show that Mg²⁺@PAM/GG hydrogel’s mechanical strength could be enhanced by the dual network structure and physical crosslinking agent Mg²⁺ ions. In addition, the tension strength of Mg²⁺@PAM/GG hydrogel is obviously increased from 86 to 392 kPa, the elongation at break increased from 84 to 231%, and crosslinking density N increased from 4.3 to 7.2 mol/m³ compared with pure GG hydrogel. The cumulative release curve of Mg²⁺ ions shows that the multiple release mechanism of Mg²⁺ ions belong to non-Fick’s diffusion. Meanwhile, in vitro experiments show that Mg²⁺@PAM/GG double network hydrogel has favorable proliferation and an NF-κB pathway inhibition property for fibroblast cells. Finally, the healing effect of the Mg²⁺@PAM/GG was evaluated in a rat full-thickness burn model. The animal study demonstrates that Mg²⁺@PAM/GG could accelerate the healing efficiency in case of the sustained-released Mg²⁺ ions in wound beds. Considering this excellent performance, this convenient prepared hydrogel has great potential as a commercial application for skin full-thickness burn healing materials.

为了方便地加速严重皮肤烧伤创面的愈合，通过化学交联和Mg ²⁺离子浸泡技术合成了由结冷胶和聚丙烯酰胺组成的互穿网络水凝胶。通过形态、水蒸气损失、溶胀率、流变性能、拉伸力学、生物相容性和流式细胞术研究对制备的Mg ²⁺ @PAM/GG水凝胶进行表征。结果表明，双网络结构和物理交联剂Mg ²⁺离子可以提高Mg ²⁺ @PAM/GG水凝胶的机械强度。此外，Mg ²⁺ @PAM/GG水凝胶的拉伸强度明显从86 kPa提高到392 kPa，断裂伸长率从84%提高到231%，交联密度N从4.3 mol/m 3 提高到7.2 mol/m ^{3 。}纯GG水凝胶。 Mg ²⁺离子的累积释放曲线表明，Mg ²⁺离子的多重释放机制属于非菲克扩散。同时，体外实验表明Mg ²⁺ @PAM/GG双网络水凝胶对成纤维细胞具有良好的增殖和NF-κB通路抑制特性。最后，在大鼠全层烧伤模型中评估了 Mg ²⁺ @PAM/GG 的愈合效果。动物研究表明，当创面持续释放Mg ²⁺离子时，Mg ²⁺ @PAM/GG 可以加速愈合效率。考虑到这种优异的性能，这种方便制备的水凝胶作为皮肤全层烧伤愈合材料的商业应用具有巨大的潜力。