Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS). The associations between coagulation and hormonal abnormalities in HFRS have not been studied yet. Forty-two patients diagnosed with Puumala virus (PUUV) infection were examined during the acute phase and on a follow-up visit approximately one month later. Hormonal defects were common during acute PUUV infection. Overt (clinical) hypogonadism was identified in 80% of the men and approximately 20% of the patients had overt hypothyroidism. At the one-month follow-up visit, six patients had central hormone deficits. Acute peripheral hormone deficits associated with a more severe acute kidney injury (AKI), longer hospital stay and more severe thrombocytopenia. Half of the patients with bleeding symptoms had also peripheral hormonal deficiencies. Patients with free thyroxine levels below the reference range had higher D-dimer level than patients with normal thyroid function, but no thromboembolic events occurred. Acute phase hormonal abnormalities associate with severe disease and altered haemostasis in PUUV infection.

中文翻译：

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荷尔蒙缺陷在普马拉汉坦病毒感染期间很常见，并且与疾病严重程度和止血改变的生物标志物有关

在急性汉坦病毒感染期间和之后记录了中枢和外周激素缺乏。血小板减少和凝血异常是肾综合征出血热 (HFRS) 的常见表现。尚未研究 HFRS 中凝血和激素异常之间的关联。在急性期和大约一个月后的随访中检查了 42 名诊断为 Puumala 病毒 (PUUV) 感染的患者。在急性 PUUV 感染期间，激素缺陷很常见。在 80% 的男性中发现了明显的（临床）性腺功能减退症，大约 20% 的患者有明显的甲状腺功能减退症。在 1 个月的随访中，有 6 名患者出现中枢激素缺乏症。与更严重的急性肾损伤 (AKI) 相关的急性外周激素缺乏，住院时间更长，血小板减少更严重。一半有出血症状的患者也有外周激素缺乏症。游离甲状腺素水平低于参考范围的患者的 D-二聚体水平高于甲状腺功能正常的患者，但未发生血栓栓塞事件。急性期荷尔蒙异常与 PUUV 感染中的严重疾病和止血改变有关。