Curcumin-mediated Photodynamic Inactivation (PDI) has shown great potential to disinfect specific sites on tooth enamel but may involve contact with restorative materials. Thus, before use in dentistry, it is necessary to investigate whether the PDI protocol causes undesirable changes in the surfaces of aesthetic restorative materials and dental enamel. This study investigated the effect of PDI mediated by curcumin (CUR) in a liquid crystal precursor system on color stability (ΔE), surface roughness (Ra), and microhardness (kgf) of three different composite resins and bovine dental enamel specimens. The microhardness and roughness readings were performed 60 days after the treatments while the color readings were performed immediately, 24, 48, and 72 h, 7, 14, 21, 30, and 60 days after the treatments. Results showed that CUR mediated-PDI does not seem to have the potential to promote any esthetic or mechanical changes to the surface of tooth enamel and can be applied safely in clinical practice. However, the results on color, roughness, and hardness obtained for composite resins show that some negative effects can be produced, depending on the type of restorative material; more experiments must be performed with different formulations and, perhaps, with lower concentrations of CUR.

中文翻译：

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生物粘附姜黄素介导的光动力灭活及其对牙齿和修复表面造成不良影响的可能性

姜黄素介导的光动力灭活 (PDI) 已显示出对牙釉质特定部位进行消毒的巨大潜力，但可能涉及与修复材料的接触。因此，在用于牙科之前，有必要调查 PDI 协议是否会导致美学修复材料和牙釉质表面发生不良变化。本研究调查了液晶前体系统中由姜黄素 (CUR) 介导的 PDI 对三种不同复合树脂和牛牙釉质样品的颜色稳定性 (ΔE)、表面粗糙度 (Ra) 和显微硬度 (kgf) 的影响。在处理后 60 天进行显微硬度和粗糙度读数，而在处理后立即、24、48 和 72 小时、7、14、21、30 和 60 天进行颜色读数。结果表明，CUR 介导的 PDI 似乎没有促进牙釉质表面的任何美学或机械变化的潜力，可以安全地应用于临床实践。然而，复合树脂的颜色、粗糙度和硬度结果表明，根据修复材料的类型，可能会产生一些负面影响；必须使用不同的配方进行更多的实验，也许使用较低的 CUR 浓度。