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Malconenoside A, a New Phenolic Glycoside from Bupleurum malconense
Natural Product Communications ( IF 1.5 ) Pub Date : 2021-09-13 , DOI: 10.1177/1934578x211037410
Jie Yan 1 , Qin Luo 2 , Fei Long 1 , Mei-Lian Zhao 3
Affiliation  

A new phenolic glycoside, 7-(4-O-β-D-glucopyranosyl, 3-methoxyphenyl)-6,8-dihydrofuro[3′,4′:7,8]naphtho[1,2-d][1,3]dioxol-10(7H)-one, named malconenoside A (1), was isolated from Bupleurum malconense Shan et Y. Li. The structure, including absolute configurations, was assigned by using spectroscopic methods and ECD calculation. Biological activities of compound 1 towards human cancer cells (HepG2, BGC-823, and A549) were evaluated. The most sensitive two cell lines were HepG2 and BGC823, in which the IC50 values of compound 1 were 8.70 and 16.94 μM, respectively.



中文翻译:

Malconenoside A,一种来自 Bupleurum malconense 的新型酚醛糖苷

一种新的酚糖苷,7-(4 - O - β -D-吡喃葡萄糖基,3-甲氧基苯基)-6,8-二氢呋喃[3',4':7,8]萘并[1,2-d][1, 3]dioxol-10(7H)-one,命名为malconenoside A ( 1 ),是从Bupleurum malconense Shan et Y. Li 中分离出来的通过使用光谱方法和 ECD 计算分配结构,包括绝对构型。评估了化合物1对人类癌细胞(HepG2、BGC-823 和 A549)的生物活性。最敏感的两个细胞系是 HepG2 和 BGC823,其中化合物1的 IC 50值分别为 8.70 和 16.94 μM。

更新日期:2021-09-13
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