Introduction

Headache is a frequent adverse event after viral vaccines. We aimed to investigate the frequency and clinical associations of COVID-19 vaccine-related headache.

Methods

The characteristics, associations of this headache, main comorbidities, headache history following the influenza vaccine and during COVID-19 were investigated using a web-based questionnaire.

Results

A total of 1819 healthcare personnel (mean age: 44.4 ± 13.4 years, 1222 females), vaccinated with inactivated virus, contributed to the survey; 209 (11.4%) had been infected with COVID-19. A total of 556 participants (30.6%) reported headache with significant female dominance (36.1% vs. 19.3%), 1.8 ± 3.5 (median: 1; IQR: 0–2) days following vaccination. One hundred and forty-four participants (25.9%) experienced headache lasting ≥3 days. Headache was mostly bilateral without accompanying phenomena, less severe, and shorter than COVID-19-related headache. The presence of primary headaches and migraine were significantly associated with COVID-19 vaccine-related headache (ORs = 2.16 [95% CI 1.74–2.68] and 1.65 [1.24–2.19], respectively). Headache during COVID-19 or following influenza vaccine also showed significant association with headache following COVID-19 vaccine (OR = 4.3 [95% CI 1.82–10.2] and OR = 4.84 [95% CI 2.84–8.23], respectively). Only thyroid diseases showed a significant association (OR = 1.54 [95% CI 1.15–2.08]) with vaccine-related headache among the common comorbidities.

Conclusion

Headache is observed in 30.6% of the healthcare workers following COVID-19 vaccine and mostly experienced by females with pre-existing primary headaches, thyroid disorders, headache during COVID-19, or headache related to the influenza vaccine.

中文翻译：

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COVID-19疫苗相关头痛的特征：从大流行中的医护人员那里收集到的线索

介绍

头痛是病毒疫苗接种后常见的不良事件。我们旨在调查 COVID-19 疫苗相关头痛的频率和临床关联。

方法

使用基于网络的问卷调查了这种头痛的特征、相关性、主要合并症、流感疫苗接种后和 COVID-19 期间的头痛史。

结果

共有 1819 名接种灭活病毒疫苗的医护人员（平均年龄：44.4 ± 13.4 岁，1222 名女性）参与了调查；209 (11.4%) 人感染了 COVID-19。共有 556 名参与者 (30.6%) 报告了在接种疫苗后 1.8 ± 3.5 天（中位数：1；IQR：0-2）天，女性占主导地位的头痛明显（36.1% 对 19.3%）。144 名参与者 (25.9%) 经历了持续 ≥3 天的头痛。头痛大多是双侧的，没有伴随的现象，比 COVID-19 相关的头痛更轻且时间更短。原发性头痛和偏头痛与 COVID-19 疫苗相关性头痛显着相关（ORs = 2.16 [95% CI 1.74–2.68] 和 1.65 [1.24–2.19]）。COVID-19 期间或流感疫苗接种后的头痛也与 COVID-19 疫苗接种后的头痛显着相关（分别为 OR = 4.3 [95% CI 1.82–10.2] 和 OR = 4.84 [95% CI 2.84–8.23]）。在常见合并症中，只有甲状腺疾病与疫苗相关性头痛显着相关（OR = 1.54 [95% CI 1.15–2.08]）。

结论

在接种 COVID-19 疫苗后，有 30.6% 的医护人员出现头痛，其中大部分是患有原发性头痛、甲状腺疾病、COVID-19 期间头痛或与流感疫苗相关的头痛的女性。