Endometriosis is an estrogen-dependent chronic inflammatory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility. The heterogeneity of the disease makes accurate diagnosis and treatment a clinical challenge. In this study, we generated two models of endometriosis: the first in rats and the second using human ectopic endometrial stromal cells (HEcESCs) derived from the lesion tissues of endometriosis patients. We then applied resveratrol to assess its therapeutic potential. Resveratrol intervention had significant efficacy to attenuate lesion size and to rectify aberrant lipid profiles of model rats. Lipidomic analysis revealed significant lipidomic alterations, including notable increases of sphingolipids and decreases of both glycerolipids and most phospholipids. Upon resveratrol application, both proliferation capacity and invasiveness parameters decreased, and the early apoptosis proportion increased for HEcESCs. The activation of PPARα was also noted as a factor potentially contributing to recovery from endometriosis in both models. Our study provides valuable insight into the mechanisms of resveratrol in endometriosis and therefore strengthens the potential for optimizing resveratrol treatment for this disease.

中文翻译：

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白藜芦醇诱导的脂质组变化和 PPARα 激活导致子宫内膜异位症模型中病变大小的减小

子宫内膜异位症是一种雌激素依赖性慢性炎症性疾病，影响约 10% 的育龄妇女和高达 50% 的不孕症妇女。该疾病的异质性使准确诊断和治疗成为临床挑战。在这项研究中，我们生成了两种子宫内膜异位症模型：第一种是大鼠模型，第二种是使用源自子宫内膜异位症患者病变组织的人异位子宫内膜基质细胞 (HEcESCs)。然后我们应用白藜芦醇来评估其治疗潜力。白藜芦醇干预对减轻病变大小和纠正模型大鼠的异常脂质谱具有显着疗效。脂质组学分析揭示了显着的脂质组学改变，包括鞘脂的显着增加以及甘油脂和大多数磷脂的减少。应用白藜芦醇后，HEcESCs的增殖能力和侵袭性参数均下降，早期凋亡比例增加。PPAR的激活在两种模型中， α也被认为是可能有助于从子宫内膜异位症中恢复的一个因素。我们的研究为白藜芦醇在子宫内膜异位症中的机制提供了有价值的见解，因此增强了优化白藜芦醇治疗该疾病的潜力。