Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity. Numerous studies in different populations across the continents have reported on the significant roles of TLR gene polymorphisms in modulating the risk of colorectal cancer (CRC). CRC is one of the major malignancies affecting the worldwide population and is currently ranking the third most common cancer in the world. In this review, we have attempted to discuss the structure, functions, and signaling of TLRs in comprehensive detail together with the role played by various TLR gene SNPs in CRC susceptibility.

中文翻译：

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Toll 样受体 (TLR)：结构、功能、信号传导及其多态性在结直肠癌易感性中的作用

Toll 样受体 (TLR) 是肠道炎症通路的重要介质，在介导对多种病原体衍生配体的免疫反应中起主要作用，并将获得性免疫与先天免疫联系起来。对各大洲不同人群的大量研究报告了 TLR 基因多态性在调节结直肠癌 (CRC) 风险中的重要作用。CRC是影响全球人口的主要恶性肿瘤之一，目前在世界上排名第三。在这篇综述中，我们试图全面详细地讨论 TLR 的结构、功能和信号传导，以及各种 TLR 基因 SNP 在 CRC 易感性中所起的作用。