Acridinone-based anion transporters,Organic & Biomolecular Chemistry

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Acridinone-based anion transporters
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2021-09-13 , DOI: 10.1039/d1ob01545a
Daniel A McNaughton ₁ , Lauren K Macreadie ₁ , Philip A Gale _{1,

2}

Affiliation

The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven to be a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective compounds in the series, which facilitated strictly electroneutral transport.

中文翻译：

基于吖啶酮的阴离子转运蛋白

氢键供体围绕中心亲脂支架的排列已被证明是开发有效氯化物转运蛋白的成功策略。在这项工作中，我们重新审视了吖啶酮 1,9-双（硫）脲基序，该基序之前已显示出作为阴离子传感器的前景，并通过在外围苯基部分附加各种吸电子基团来扩展化合物系列。该系列中最有效的化合物实现了高水平的活性，这促进了严格的电中性传输。

更新日期：2021-09-13

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