ABSTRACT

Background and Purpose: Quantitative electroencephalogram (QEEG) parameters have been previously utilized in prognosis following acute ischemic stroke (AIS). However, the use and interpretation of QEEG parameters remain scarce following endovascular treatment (EVT) of AIS.

Methods: AIS patients were prospectively enrolled following EVT, and 24-hour EEG monitoring was conducted. Global delta/alpha ratio (DAR), (delta + theta)/(alpha + beta) ratio (DTABR), and relative band power were analyzed. Primary outcome was a poor outcome (modified Rankin Scale ≥4 at 90-day follow-up). Multivariate logistic regression and diagnostic analyses were performed.

Results: Poor outcome was seen in 35.5% (11/31) of enrolled patients. Multivariable logistic regression identified that higher DAR (OR 1.10, 95% CI 1.02–1.18, p = 0.02) and higher DTABR (OR 1.13, 95% CI 1.01–1.27, p = 0.02) were associated with poor outcome. DAR ≥14.3 demonstrated high sensitivity (90.9%), specificity (90.0%) and accuracy (90.3%) for poor outcome.

Conclusions: Early evidence of elevated DAR and DTABR on quantitative EEG was associated with poor outcome at 90 days following EVT for AIS.

摘要

背景和目的：定量脑电图 (QEEG) 参数以前已用于急性缺血性卒中 (AIS) 后的预后。然而，在 AIS 的血管内治疗 (EVT) 之后，QEEG 参数的使用和解释仍然很少。

方法： AIS 患者在 EVT 后前瞻性入组，并进行 24 小时脑电图监测。分析了全局 delta/alpha 比率 (DAR)、(delta + theta)/(alpha + beta) 比率 (DTABR) 和相对波段功率。主要结局为不良结局（90 天随访时改良 Rankin 量表≥4）。进行了多变量逻辑回归和诊断分析。

结果： 35.5% (11/31) 的入组患者出现不良结果。多变量逻辑回归发现较高的 DAR (OR 1.10, 95% CI 1.02–1.18, p = 0.02) 和较高的 DTABR (OR 1.13, 95% CI 1.01–1.27, p = 0.02) 与不良结果相关。DAR ≥14.3 对不良结果表现出高灵敏度 (90.9%)、特异性 (90.0%) 和准确度 (90.3%)。

结论：定量 EEG 中 DAR 和 DTABR 升高的早期证据与 AIS EVT 后 90 天的不良结果相关。