We report a novel highly sensitive bile acids (cholic acid and deoxycholic acid) biosensor based on PVA/SC₁₂S-stabilized cholesteric liquid crystal droplets. These CLC droplets are monodisperse in nature and are generated by fabricating a capillary microfluidic flow focusing device. The homeotropic-to-planar transition of the CLC droplets will be triggered during the competitive adsorption of bile acids at the surface of the CLC droplets. This sensor detects bile acids at a minimal cost and in a simple and quick manner. The detection limit of our method for CA is (1 μM) 80% lower and for DCA is 50% lower than that of the previously reported method using nematic droplets for detection. Furthermore, the response times and detection limits of these bile acids can be adjusted as a function of the pH, bile acid volume, and droplet size. Bile acids can be identified without the use of crossed polarizers using this novel method.

中文翻译：

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使用基于胆甾型液晶液滴的光学生物传感器检测胆汁酸

我们报告了一种基于PVA / SC ₁₂ S稳定胆甾型液晶液滴的新型高灵敏度胆汁酸（胆酸和脱氧胆酸）生物传感器。这些CLC液滴本质上是单分散的，是通过制造毛细管微流体流动聚焦装置产生的。在胆汁酸在CLC液滴表面的竞争吸附过程中，将触发CLC液滴的垂直到平面转变。该传感器以最低的成本和简单快捷的方式检测胆汁酸。我们的方法对CA的检测限为 (1 μM) 80%，而对于DCA比之前报道的使用向列液滴进行检测的方法低 50%。此外，这些胆汁酸的响应时间和检测限可以根据 pH 值、胆汁酸体积和液滴大小进行调整。使用这种新方法可以在不使用交叉偏振器的情况下识别胆汁酸。