A voltammetric sensor based on a carbon black and chitosan-stabilized gold nanoparticle nanocomposite for ketoconazole determination,Analytical Methods

当前位置： X-MOL 学术 › Anal. Methods › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A voltammetric sensor based on a carbon black and chitosan-stabilized gold nanoparticle nanocomposite for ketoconazole determination
Analytical Methods ( IF 2.7 ) Pub Date : 2021-08-24 , DOI: 10.1039/d1ay01321a
Laís Pereira Silva ₁ , Tiago Almeida Silva ₂ , Fernando Cruz Moraes ₁ , Orlando Fatibello-Filho ₁

Affiliation

A modified glassy carbon electrode with carbon black (CB) and gold nanoparticles (AuNPs) within a crosslinked chitosan (CTS) film is proposed in this work. The electroanalytical performance of the modified CB-CTS-AuNPs/GCE has been evaluated towards the voltammetric sensing of ketoconazole (KTO), a widespread antifungal drug. The nanocomposite was characterized by scanning electron microscopy, X-ray diffraction spectroscopy, and electrochemistry experiments. The evaluation of the electrochemical behaviour of KTO on the proposed modified electrode shows an irreversible oxidation process at a potential of +0.65 V (vs. Ag/AgCl (3.0 mol L⁻¹ KCl)). This redox process was explored to carry out KTO sensing using square-wave voltammetry. The analytical curve was linear in the KTO concentration range from 0.10 to 2.9 μmol L⁻¹, with a limit of detection (LOD) of 4.4 nmol L⁻¹ and a sensitivity of 3.6 μA L μmol⁻¹. This modified electrode was successfully applied to the determination of KTO in pharmaceutical formulations and biological fluid samples.

中文翻译：

基于炭黑和壳聚糖稳定的金纳米颗粒纳米复合材料的伏安传感器用于测定酮康唑

在这项工作中提出了一种在交联壳聚糖 (CTS) 膜中具有炭黑 (CB) 和金纳米粒子 (AuNPs) 的改性玻碳电极。改进后的 CB-CTS-AuNPs/GCE 的电分析性能已针对酮康唑 (KTO)（一种广泛使用的抗真菌药物）的伏安传感进行了评估。通过扫描电子显微镜、X 射线衍射光谱和电化学实验表征纳米复合材料。对所提出的修饰电极上 KTO 电化学行为的评估表明，在 +0.65 V ( vs. Ag/AgCl (3.0 mol L ^-1氯化钾））。探索了这种氧化还原过程以使用方波伏安法进行 KTO 感测。分析曲线在0.10至2.9 μmol L ^-1的KTO浓度范围内呈线性，检测限(LOD)为4.4 nmol L ^-1，灵敏度为3.6 μA L μmol ^-1。该修饰电极成功应用于药物制剂和生物体液样品中 KTO 的测定。

更新日期：2021-09-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11