Two ecocatalysts Eco-MG1 and Eco-MG2 were obtained from the biomass of Miscanthus x giganteus cultivated in situ on metal-contaminated soils from the North-of-France region. Ecocatalysts have been characterized by SEM-EDS analyses and flame atomic absorption spectrometry and used to synthesize new urolithins A and B derivatives, metabolites of ellagic acid, through Hurtley reaction between polyphenols and bromobenzoic acids in water and/or in ethanol. Eco-MG2 was the most effective catalyst in the synthesis of urolithin derivatives and exceeded the catalytic power of copper sulphate (CuSO₄) conventionally used in this benzo[c]chromene ring-closure Hurtley reaction. Newly synthesized urolithins 1–24 have been evaluated for their ability to inhibit the AGE2-BSA/sRAGE interaction and compared to known RAGE antagonists (Azeliragon, FPS-ZM1, etc). Urolithins showed excellent inhibitory activities equivalent to reference Azeliragon and constitute promising RAGE antagonists with anti-ageing properties. The first SAR were identified and open the way to the development of new series of experimental drugs targeting RAGE.

两种生态催化剂 Eco-MG1 和 Eco-MG2 是从法国北部地区金属污染土壤上原位栽培的芒草的生物质中获得的。生态催化剂已通过 SEM-EDS 分析和火焰原子吸收光谱法表征，并用于通过多酚和溴苯甲酸在水中和/或乙醇中的 Hurtley 反应合成新的尿石素 A 和 B 衍生物，即鞣花酸的代谢物。Eco-MG2 是合成尿石素衍生物中最有效的催化剂，其催化能力超过了苯并 [ c ] 色烯闭环 Hurtley 反应中常用的硫酸铜 (CuSO ₄ ) 。新合成的尿石素1 –24已评估其抑制 AGE2-BSA/sRAGE 相互作用的能力，并与已知的 RAGE 拮抗剂（Azeliragon、FPS-ZM1 等）进行比较。尿石素显示出与参考 Azeliragon 相当的优异抑制活性，并构成具有抗衰老特性的有前途的 RAGE 拮抗剂。第一个 SAR 被确定，并为开发针对 RAGE 的新系列实验药物开辟了道路。