Fibroblasts are a major non-neoplastic component of solid tumors, yet it is unclear whether they promote or oppose cancer. In this issue of Cancer Cell, Hutton et al. report two distinct fibroblast subpopulations that are defined by a single marker, one subpopulation that is tumor permissive and the other that is tumor suppressive and supports anti-tumor immunity.

中文翻译：

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成纤维细胞的两个相反亚群决定胰腺癌的进展

成纤维细胞是实体瘤的主要非肿瘤成分，但尚不清楚它们是否促进或对抗癌症。在本期《癌细胞》中，Hutton 等人。报告了由单一标记物定义的两种不同的成纤维细胞亚群，一种是肿瘤许可的亚群，另一种是肿瘤抑制的并支持抗肿瘤免疫。