Injectable Lignin-co-Gelatin Cryogels with Antioxidant and Antibacterial Properties for Biomedical Applications,Biomacromolecules

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Injectable Lignin-co-Gelatin Cryogels with Antioxidant and Antibacterial Properties for Biomedical Applications
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-09-13 , DOI: 10.1021/acs.biomac.1c00575
Turdimuhammad Abudula ₁ , Thibault Colombani ₂ , Taofeek Alade ₁ , Sidi A Bencherif _{2,

3,

4,

5} , Adnan Memić ₁

Affiliation

For several biomedical applications, it is essential to develop novel bioactive materials. Such biomaterials could potentially improve wound healing, prevent infections, or be used in immunoengineering. For example, bioactive materials that reduce oxidative stress without relying on antibiotics and other drugs could be beneficial. Hydrogel-based biomaterials, especially those derived from natural polymers, have been regarded as one of the most promising scaffolds for biomedical research. These multifunctional scaffolds can exhibit high water adsorption capacity, biocompatibility, and biomechanical properties that can match native tissues. Cryogels are a special type of hydrogels in which polymers are cross-linked around ice crystals. As a result, cryogels exhibit unique physical features, including a macroporous and interconnected network, flexibility, shape-memory properties, and syringe injectability. Herein, we developed a multifunctional, i.e., antibacterial, antioxidant, and injectable cryogel by combining lignin with gelatin. The cryogel with 0.2% lignin showed a compressive modulus of 25 kPa and a compressive stress of 140 kPa at 80% strain, which is, respectively, 1.8 and 7 times higher than those of the pure gelatin cryogels. Meanwhile, such a cryogel formulation could completely recover its shape after compression up to 90% and was needle-injectable. Additionally, the lignin-co-gelatin cryogel with 0.1–0.2 lignin showed 8–10 mm of inhibition zone against the most common surgical site infection-associated pathogenic bacteria. Furthermore, lignin-co-gelatin cryogel was found to scavenge free radicals and have good cytocompatibility, and the cryogels with up to 0.2% lignin minimally activate naïve mouse bone marrow-derived dendritic cells. Overall, the current approach shows great promise for the design of bioresource-based multifunctional cryogels for a wide range of biomedical applications.

中文翻译：

用于生物医学应用的具有抗氧化和抗菌特性的可注射木质素-co-明胶冷冻凝胶

对于多种生物医学应用，开发新型生物活性材料至关重要。这种生物材料可能会改善伤口愈合、预防感染或用于免疫工程。例如，在不依赖抗生素和其他药物的情况下减少氧化应激的生物活性材料可能是有益的。基于水凝胶的生物材料，尤其是源自天然聚合物的生物材料，被认为是生物医学研究中最有前途的支架之一。这些多功能支架可以表现出与天然组织相匹配的高吸水能力、生物相容性和生物力学特性。冷冻凝胶是一种特殊类型的水凝胶，其中聚合物在冰晶周围交联。因此，冷冻凝胶表现出独特的物理特征，包括大孔和相互连接的网络，灵活性、形状记忆特性和注射器可注射性。在此，我们通过将木质素与明胶相结合，开发了一种多功能，即抗菌、抗氧化和可注射的冷冻凝胶。含 0.2% 木质素的冷冻凝胶在 80% 应变下的压缩模量为 25 kPa，压缩应力为 140 kPa，分别是纯明胶冷冻凝胶的 1.8 倍和 7 倍。同时，这种冷冻凝胶配方在压缩高达 90% 后可以完全恢复其形状，并且可以针刺。此外，木质素- 2% 木质素在 80% 应变下的压缩模量为 25 kPa，压缩应力为 140 kPa，分别是纯明胶冷冻凝胶的 1.8 倍和 7 倍。同时，这种冷冻凝胶配方在压缩高达 90% 后可以完全恢复其形状，并且可以针刺。此外，木质素- 2% 木质素在 80% 应变下的压缩模量为 25 kPa，压缩应力为 140 kPa，分别是纯明胶冷冻凝胶的 1.8 倍和 7 倍。同时，这种冷冻凝胶配方在压缩高达 90% 后可以完全恢复其形状，并且可以针刺。此外，木质素-含有 0.1-0.2 木质素的共明胶冷冻凝胶对最常见的手术部位感染相关病原菌具有 8-10 mm 的抑菌圈。此外，发现木质素-co-明胶冷冻凝胶可清除自由基并具有良好的细胞相容性，并且含有高达 0.2% 木质素的冷冻凝胶可最小程度地激活幼稚小鼠骨髓来源的树突状细胞。总体而言，目前的方法显示出为广泛的生物医学应用设计基于生物资源的多功能冷冻凝胶的巨大希望。

更新日期：2021-10-12

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