Tailored Biosensors for Drug Screening, Efficacy Assessment, and Toxicity Evaluation,ACS Sensors

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Tailored Biosensors for Drug Screening, Efficacy Assessment, and Toxicity Evaluation
ACS Sensors ( IF 8.2 ) Pub Date : 2021-09-13 , DOI: 10.1021/acssensors.1c01600
Yi Tao ₁ , Lin Chen ₁ , Meiling Pan ₁ , Fei Zhu ₁ , Dong Zhu ₂

Affiliation

Biosensors have been flourishing in the field of drug discovery with pronounced developments in the past few years. They facilitate the screening and discovery of innovative drugs. However, there is still a lack of critical reviews that compare the merits and shortcomings of these biosensors from a pharmaceutical point of view. This contribution presents a critical and up-to-date overview on the recent progress of tailored biosensors, including surface plasmon resonance, fluorescent, photoelectrochemical, and electrochemical systems with emphasis on their mechanisms and applications in drug screening, efficacy assessment, and toxicity evaluation. Multiple functional nanomaterials have also been incorporated into the biosensors. Representative examples of each type of biosensors are discussed in terms of design strategy, response mechanism, and potential applications. In the end, we also compare the results and summarize the major insights gained from the works, demonstrating the challenges and prospects of biosensors-assisted drug discovery.

中文翻译：

用于药物筛选、功效评估和毒性评估的定制生物传感器

生物传感器在药物发现领域蓬勃发展，在过去几年中取得了显着的发展。它们促进了创新药物的筛选和发现。然而，仍然缺乏从制药角度比较这些生物传感器的优缺点的批评性评论。该贡献对定制生物传感器的最新进展进行了重要和最新的概述，包括表面等离子体共振、荧光、光电化学和电化学系统，重点介绍了它们在药物筛选、功效评估和毒性评估中的机制和应用。多种功能纳米材料也已被纳入生物传感器。从设计策略、响应机制、和潜在的应用。最后，我们还比较了结果并总结了从工作中获得的主要见解，展示了生物传感器辅助药物发现的挑战和前景。

更新日期：2021-09-24

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