Abstract

Controlling inflammation can alleviate immune-mediated, lifestyle-related and neurodegenerative diseases. The endolysosome system plays critical roles in inflammatory responses. Endolysosomes function as signal transduction hubs to convert various environmental danger signals into gene expression, enabling metabolic adaptation of immune cells and efficient orchestration of inflammation. Solute carrier family 15 member 3 (SLC15A3) and member 4 (SLC15A4) are endolysosome-resident amino acid transporters that are preferentially expressed in immune cells. These transporters play essential roles in signal transduction through endolysosomes, and the loss of either transporter can alleviate multiple inflammatory diseases because of perturbed endolysosome-dependent signaling events, including inflammatory and metabolic signaling. Here, we summarize the findings leading to a proof-of-concept for anti-inflammatory strategies based on targeting SLC15 transporters.

中文翻译：

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溶酶体氨基酸转运蛋白是炎症性疾病的关键参与者

摘要

控制炎症可以缓解免疫介导的、生活方式相关的和神经退行性疾病。内溶酶体系统在炎症反应中起关键作用。内溶酶体充当信号转导枢纽，将各种环境危险信号转化为基因表达，从而实现免疫细胞的代谢适应和炎症的有效协调。溶质载体家族 15 成员 3 (SLC15A3) 和成员 4 (SLC15A4) 是内溶酶体驻留的氨基酸转运蛋白，优先在免疫细胞中表达。这些转运蛋白在通过内溶酶体的信号转导中发挥重要作用，并且由于内溶酶体依赖性信号传导事件（包括炎症和代谢信号传导）受到干扰，任何一种转运蛋白的缺失都可以缓解多种炎症性疾病。这里，