Research question

Does mild COVID-19 infection affect the ovarian reserve of women undergoing an assisted reproductive technology (ART) protocol?

Design

A prospective observational study was conducted between June and December 2020 at the ART unit of Tenon Hospital, Paris. Women managed at the unit for fertility issues by in-vitro fecundation, intracytoplasmic sperm injection (IVF/ICSI), fertility preservation, frozen embryo transfer or artificial insemination, and with an anti-Müllerian hormone (AMH) test carried out within 12 months preceding ART treatment, were included. All the women underwent a COVID rapid detection test (RDT) and AMH concentrations between those who tested positive (RDT positive) and those who tested negative (RDT negative).

Results

The study population consisted of 118 women, 11.9% (14/118) of whom were COVID RDT positive. None of the tested women presented with a history of severe COVID-19 infection. The difference between the initial AMH concentration and AMH concentration tested during ART treatment was not significantly different between the COVID RDT positive group and COVID RDT negative group (–1.33 ng/ml [–0.35 to –1.61) versus –0.59 ng/ml [–0.15 to –1.11], P = 0.22).

Conclusion

A history of mild COVID-19 infection does not seem to alter the ovarian reserve as evaluated by AMH concentrations. Although these results are reassuring, further studies are necessary to assess the effect of COVID-19 on pregnancy outcomes in women undergoing ART.

中文翻译：

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轻度 COVID-19 感染不会改变接受 ART 治疗的女性的卵巢储备

研究问题

轻度 COVID-19 感染是否会影响接受辅助生殖技术 (ART) 方案的女性的卵巢储备？

设计

一项前瞻性观察研究于 2020 年 6 月至 2020 年 12 月在巴黎 Tenon 医院的 ART 部门进行。通过体外受精、卵胞浆内单精子注射 (IVF/ICSI)、生育力保存、冷冻胚胎移植或人工授精以及在前 12 个月内进行的抗苗勒管激素 (AMH) 测试，在该部门管理生育问题的妇女ART 治疗，包括在内。所有女性都接受了 COVID 快速检测测试 (RDT) 和测试阳性 (RDT 阳性) 和阴性 (RDT 阴性) 之间的 AMH 浓度。

结果

研究人群由 118 名女性组成，其中 11.9% (14/118) 为 COVID RDT 阳性。接受测试的女性都没有严重的 COVID-19 感染史。COVID RDT 阳性组和 COVID RDT 阴性组（–1.33 ng/ml [–0.35 至–1.61）与–0.59 ng/ml [– 0.15 到 –1.11]，P  = 0.22）。

结论

根据 AMH 浓度评估，轻度 COVID-19 感染史似乎不会改变卵巢储备。尽管这些结果令人欣慰，但仍需进一步研究以评估 COVID-19 对接受 ART 妇女妊娠结局的影响。