Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these disorders is also influenced by genetics and have heritability estimates ranging between ∼30 and 70%. In this review, we provide an overview of the findings of genome-wide association studies for PTSD, depression and ANX, and we observe a clear genetic overlap between these three diagnostic categories. We go on to highlight the results from transcriptomic and epigenomic studies, and, given the multifactorial nature of stress-related disorders, we provide an overview of the gene-environment studies that have been conducted to date. Finally, we discuss systems biology approaches that are now seeing wider utility in determining a more holistic view of these complex disorders.

许多人在一生中都会遭受某种形式的创伤性压力，这反过来又增加了患上与压力相关的疾病的可能性，例如创伤后应激障碍（PTSD）、重度抑郁症（MDD）和焦虑症（ANX） ）。这些疾病的发展也受到遗传的影响，遗传力估计在 30% 到 70% 之间。在这篇综述中，我们概述了 PTSD、抑郁症和 ANX 的全基因组关联研究的结果，我们观察到这三个诊断类别之间存在明显的遗传重叠。我们继续重点介绍转录组学和表观基因组研究的结果，并且考虑到应激相关疾病的多因素性质，我们概述了迄今为止已进行的基因环境研究。最后，我们讨论系统生物学方法，这些方法现在在确定这些复杂疾病的更全面的观点方面具有更广泛的用途。