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Effect of blueberry (Vaccinium virgatum) extract on depressive-like behavior and metabolic serum alterations in lipopolysaccharide-challenged mice
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-09-12 , DOI: 10.1111/jfbc.13920 Solange Vega Custódio 1 , Luiza Spohr 1 , Natália Pontes Bona 2 , Anita Avila de Souza 1 , Bernardo de Moraes Meine 2 , Sara Keske 1 , Karina Pereira Luduvico 2 , Fernando Lopez Alvez 1 , Roselia Maria Spanevello 1 , Francieli Moro Stefanello 2 , Mayara Sandrielly Pereira Soares 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-09-12 , DOI: 10.1111/jfbc.13920 Solange Vega Custódio 1 , Luiza Spohr 1 , Natália Pontes Bona 2 , Anita Avila de Souza 1 , Bernardo de Moraes Meine 2 , Sara Keske 1 , Karina Pereira Luduvico 2 , Fernando Lopez Alvez 1 , Roselia Maria Spanevello 1 , Francieli Moro Stefanello 2 , Mayara Sandrielly Pereira Soares 1
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In the present study, we aimed to investigate the protective effect of blueberry extract on behavioral, biochemical, and morphological changes in an experimental model of lipopolysaccharide (LPS)-induced depressive behavior. Male Swiss mice were pretreated with the vehicle, fluoxetine (20 mg/kg), or Vaccinium virgatum extract (100 mg/kg and 200 mg/kg) for seven days. On day 7, the animals were administered an LPS injection (0.83 mg/kg) or vehicle. Pretreatment with blueberry extract prevented LPS-induced depressive-like behavior. Moreover, LPS increased serum levels of total cholesterol; however, V. virgatum did not prevent the increase in total cholesterol levels. Furthermore, the extract prevented the LPS-induced elevation in serum reactive oxygen species. Also, V. virgatum extract increased the HDL cholesterol levels. Additionally, this extract prevented the LPS-induced decrease in glucose levels and serum adenosine deaminase activity. Collectively, V. virgatum extract has a potential protective effect against changes similar to those observed in patients with depression.
中文翻译：
蓝莓（Vaccinium virgatum）提取物对脂多糖攻击小鼠抑郁样行为和代谢血清改变的影响
在本研究中，我们旨在研究蓝莓提取物对脂多糖 (LPS) 诱导的抑郁行为实验模型的行为、生化和形态变化的保护作用。雄性瑞士小鼠用载体、氟西汀（20 毫克/千克）或越橘提取物（100 毫克/千克和 200 毫克/千克）预处理7 天。在第 7 天，给动物注射 LPS 注射液 (0.83 mg/kg) 或载体。用蓝莓提取物预处理可防止 LPS 诱导的抑郁样行为。此外，LPS 增加血清总胆固醇水平；然而，V。处女座并没有阻止总胆固醇水平的增加。此外，该提取物可防止 LPS 诱导的血清活性氧浓度升高。此外，V。virgatum提取物增加了高密度脂蛋白胆固醇水平。此外，该提取物可防止 LPS 诱导的葡萄糖水平和血清腺苷脱氨酶活性降低。总而言之，V。virgatum提取物对与抑郁症患者观察到的变化相似的变化具有潜在的保护作用。
更新日期：2021-10-06
中文翻译：
蓝莓（Vaccinium virgatum）提取物对脂多糖攻击小鼠抑郁样行为和代谢血清改变的影响
在本研究中，我们旨在研究蓝莓提取物对脂多糖 (LPS) 诱导的抑郁行为实验模型的行为、生化和形态变化的保护作用。雄性瑞士小鼠用载体、氟西汀（20 毫克/千克）或越橘提取物（100 毫克/千克和 200 毫克/千克）预处理7 天。在第 7 天，给动物注射 LPS 注射液 (0.83 mg/kg) 或载体。用蓝莓提取物预处理可防止 LPS 诱导的抑郁样行为。此外，LPS 增加血清总胆固醇水平；然而，V。处女座并没有阻止总胆固醇水平的增加。此外，该提取物可防止 LPS 诱导的血清活性氧浓度升高。此外，V。virgatum提取物增加了高密度脂蛋白胆固醇水平。此外，该提取物可防止 LPS 诱导的葡萄糖水平和血清腺苷脱氨酶活性降低。总而言之，V。virgatum提取物对与抑郁症患者观察到的变化相似的变化具有潜在的保护作用。
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