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Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-08 , DOI: 10.3233/jad-210333
Fennie Choy Chin Wong 1 , Seyed Ehsan Saffari 1, 2 , Chathuri Yatawara 1 , Kok Pin Ng 1, 3, 4 , Nagaendran Kandiah 1, 3, 4 ,
Affiliation  

Background:The associations between small vessel disease (SVD) and cerebrospinal amyloid-β1-42 (Aβ1-42) pathology have not been well-elucidated. Objective:Baseline (BL) white matter hyperintensities (WMH) were examined for associations with month-24 (M24) and longitudinal Aβ1-42 change in cognitively normal (CN) subjects. The interaction of WMH and Aβ1-42 on memory and executive function were also examined. Methods:This study included 72 subjects from the Alzheimer’s Disease Neuroimaging Initiative. Multivariable linear regression models evaluated associations between baseline WMH/intracranial volume ratio, M24 and change in Aβ1-42 over two years. Linear mixed effects models evaluated interactions between BL WMH/ICV and Aβ1-42 on memory and executive function. Results:Mean age of the subjects (Nmales = 36) = 73.80 years, SD = 6.73; mean education years = 17.1, SD = 2.4. BL WMH was significantly associated with M24 Aβ1-42 (p = 0.008) and two-year change in Aβ1-42 (p = 0.006). Interaction between higher WMH and lower Aβ1-42 at baseline was significantly associated with worse memory at baseline and M24 (p = 0.003). Conclusion:BL WMH was associated with M24 and longitudinal Aβ1-42 change in CN. The interaction between higher WMH and lower Aβ1-42 was associated with poorer memory. Since SVD is associated with longitudinal Aβ1-42 pathology, and the interaction of both factors is linked to poorer cognitive outcomes, the mitigation of SVD may be correlated with reduced amyloid pathology and milder cognitive deterioration in Alzheimer’s disease.

中文翻译:

白质高信号对认知正常个体基线和纵向淀粉样蛋白-β 的影响

背景:小血管病 (SVD) 与脑脊髓淀粉样蛋白-β1-42 (Aβ1-42) 病理之间的关联尚未得到很好的阐明。目的:检查基线 (BL) 白质高信号 (WMH) 与认知正常 (CN) 受试者的第 24 个月 (M24) 和纵向 Aβ1-42 变化的关联。还检查了 WMH 和 Aβ1-42 对记忆和执行功能的相互作用。方法:这项研究包括来自阿尔茨海默病神经影像学计划的 72 名受试者。多变量线性回归模型评估了基线 WMH/颅内容积比、M24 和两年内 Aβ1-42 变化之间的关联。线性混合效应模型评估了 BL WMH/ICV 和 Aβ1-42 之间对记忆和执行功能的相互作用。结果:受试者平均年龄(Nmales = 36) = 73.80 岁,SD = 6.73;平均教育年数 = 17.1,SD = 2.4。BL WMH 与 M24 Aβ1-42 (p = 0.008) 和 Aβ1-42 的两年变化 (p = 0.006) 显着相关。基线时较高的 WMH 和较低的 Aβ1-42 之间的相互作用与基线和 M24 时较差的记忆力显着相关(p = 0.003)。结论:BL WMH 与 CN 的 M24 和纵向 Aβ1-42 变化有关。较高的 WMH 和较低的 Aβ1-42 之间的相互作用与较差的记忆力有关。由于 SVD 与纵向 Aβ1-42 病理相关,并且这两个因素的相互作用与较差的认知结果有关,因此 SVD 的缓解可能与淀粉样蛋白病理减少和阿尔茨海默病的轻度认知恶化相关。基线时较高的 WMH 和较低的 Aβ1-42 之间的相互作用与基线和 M24 时较差的记忆力显着相关(p = 0.003)。结论:BL WMH 与 CN 的 M24 和纵向 Aβ1-42 变化有关。较高的 WMH 和较低的 Aβ1-42 之间的相互作用与较差的记忆力有关。由于 SVD 与纵向 Aβ1-42 病理相关,并且这两个因素的相互作用与较差的认知结果有关,因此 SVD 的缓解可能与淀粉样蛋白病理减少和阿尔茨海默病的轻度认知恶化相关。基线时较高的 WMH 和较低的 Aβ1-42 之间的相互作用与基线和 M24 时较差的记忆力显着相关(p = 0.003)。结论:BL WMH 与 CN 的 M24 和纵向 Aβ1-42 变化有关。较高的 WMH 和较低的 Aβ1-42 之间的相互作用与较差的记忆力有关。由于 SVD 与纵向 Aβ1-42 病理相关,并且这两个因素的相互作用与较差的认知结果有关,因此 SVD 的缓解可能与淀粉样蛋白病理减少和阿尔茨海默病的轻度认知恶化相关。较高的 WMH 和较低的 Aβ1-42 之间的相互作用与较差的记忆力有关。由于 SVD 与纵向 Aβ1-42 病理相关,并且这两个因素的相互作用与较差的认知结果有关,因此 SVD 的缓解可能与淀粉样蛋白病理减少和阿尔茨海默病的轻度认知恶化相关。较高的 WMH 和较低的 Aβ1-42 之间的相互作用与较差的记忆力有关。由于 SVD 与纵向 Aβ1-42 病理相关,并且这两个因素的相互作用与较差的认知结果有关,因此 SVD 的缓解可能与淀粉样蛋白病理减少和阿尔茨海默病的轻度认知恶化相关。
更新日期:2021-09-12
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