BACKGROUND:Diabetes mellitus is a common disorder with the risk of vascular injury. OBJECTIVE:The aim of this study was to compare the effects of low-intensity resistance exercise with blood flow restriction versus high-intensity resistance exercise on platelet CD markers and indices in patients with type 2 diabetes. METHODS:Fifteen female patients with type 2 diabetes (Mean±SD; age, 47.6±7.2 yrs) randomly completed two resistance exercise at an intensity corresponding to 20% and 80% of one-repetition maximum (1-RM), with and without blood flow restriction (REBFR and RE), respectively. We measured markers of platelet activation (P-selectin, GpIIb/IIIa, and CD42) and platelet indices before and immediately after exercise, and after 30 min recovery. RESULTS:Platelet count (PLT) and plateletcrit (PCT) increased in response to REBFR more than the RE (p < 0.05), though, no significant differences in PDW and MPV were observed (p < 0.05). Although P-selectin (CD62P), CD61, CD41, and CD42 were reduced following resistance exercise in both trials, these reductions were non-significant (p < 0.05). Besides, no significant between-group differences were found for platelet CD markers (p < 0.05). CONCLUSIONS:It is concluded that REBFR induces thrombocytosis, but responses of platelet CD markers in patients with type 2 diabetes are similar following low-intensity REBFR and high-intensity RE.

中文翻译：

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2型糖尿病患者血小板CD标志物和指标对有和无血流限制的阻力运动的反应

背景：糖尿病是一种具有血管损伤风险的常见疾病。目的：本研究的目的是比较低强度阻力运动加血流限制与高强度阻力运动对 2 型糖尿病患者血小板 CD 标志物和指标的影响。方法：15 名女性 2 型糖尿病患者（平均值±标准差；年龄，47.6±7.2 岁）随机完成了两次抗阻运动，强度分别为一次重复最大值 (1-RM) 的 20% 和 80%，有和没有血流限制（REBFR 和 RE）。我们在运动前后以及恢复 30 分钟后测量了血小板活化标志物（P-选择素、GpIIb/IIIa 和 CD42）和血小板指数。结果：血小板计数 (PLT) 和血小板比容 (PCT) 对 REBFR 的反应比 RE 增加更多（p < 0.05），但未观察到 PDW 和 MPV 的显着差异（p < 0.05）。尽管 P-选择素 (CD62P)、CD61、CD41 和 CD42 在两项试验中的阻力运动后均有所降低，但这些降低并不显着 (p < 0.05)。此外，未发现血小板 CD 标志物的显着组间差异（p < 0.05）。结论：结论 REBFR 可诱导血小板增多，但 2 型糖尿病患者血小板 CD 标志物的反应在低强度 REBFR 和高强度 RE 后相似。这些减少并不显着（p < 0.05）。此外，未发现血小板 CD 标志物的显着组间差异（p < 0.05）。结论：结论 REBFR 可诱导血小板增多，但 2 型糖尿病患者血小板 CD 标志物的反应在低强度 REBFR 和高强度 RE 后相似。这些减少并不显着（p < 0.05）。此外，未发现血小板 CD 标志物的显着组间差异（p < 0.05）。结论：结论 REBFR 可诱导血小板增多，但 2 型糖尿病患者血小板 CD 标志物的反应在低强度 REBFR 和高强度 RE 后相似。