BACKGROUND:Age-related mechanisms of sarcopenia associated with vascular function have been recently suggested. This study compared and tested associations between muscle mass and strength, microcirculation, inflammatory biomarkers, and oxidative stress in older adults classified as sarcopenic andnon-sarcopenic. METHODS:Thirty-three physically inactive individuals (72±7 yrs) were assigned to age-matched sarcopenic (SG) and non-sarcopenic (NSG) groups. Between-group comparisons were performed for appendicular skeletal mass (ASM), handgrip and isokinetic strength, microvascular function and morphology, C-reactive protein, insulin-like growth factor-1, tumor necrosis factor-alpha, interleukin-6 (IL-6), soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, endothelin-1, and oxidized low-density lipoprotein. RESULTS:ASM and knee isokinetic strength were lower in SG than NSG (P < 0.05). No difference between groups was found for outcomes of microvascular function and morphology, but log-transformed IL-6 concentration was twice greater in SG vs. NSG (P = 0.02). Correlations between ASM index, handgrip and knee isokinetic strength vs. markers of microcirculatory function, capillary diameters, vascular reactivity, and endothelial injury were found only in SG. CONCLUSION:Decreased ASM index and strength have been associated with microcirculatory profile, indicating that microcirculation impairment may be involved somehow in Sarcopenia development. The inflammation status, particularly elevated IL-6, seems to play an important role in this process.

中文翻译：

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老年人肌肉减少症与微循环、炎症状态和氧化应激：一项横断面研究

背景：最近提出了与血管功能相关的肌肉减少症的年龄相关机制。这项研究比较并测试了老年人肌肉质量与力量、微循环、炎症生物标志物和氧化应激之间的关联，这些老年人被归类为少肌症和非少肌症。方法：33 名身体不活跃的个体（72±7 岁）被分配到年龄匹配的少肌症（SG）和非少肌症（NSG）组。对阑尾骨骼质量 (ASM)、握力和等速强度、微血管功能和形态、C 反应蛋白、胰岛素样生长因子-1、肿瘤坏死因子-α、白细胞介素-6 (IL-6) 进行组间比较)、可溶性血管细胞粘附分子-1、可溶性细胞间粘附分子-1、内皮素-1和氧化低密度脂蛋白。结果：SG 组的 ASM 和膝关节等速力量低于 NSG（P < 0.05）。微血管功能和形态学结果未发现组间差异，但对数转换后的 IL-6 浓度在 SG 与 NSG 中高出两倍（P = 0.02）。ASM 指数、握力和膝关节等速力量与微循环功能标志物、毛细血管直径、血管反应性和内皮损伤之间的相关性仅在 SG 中发现。结论：ASM指数和强度的降低与微循环特征有关，表明微循环障碍可能在某种程度上参与了肌肉减少症的发展。炎症状态，尤其是升高的 IL-6，似乎在这一过程中发挥了重要作用。微血管功能和形态学结果未发现组间差异，但对数转换后的 IL-6 浓度在 SG 与 NSG 中高出两倍（P = 0.02）。ASM 指数、握力和膝关节等速力量与微循环功能标志物、毛细血管直径、血管反应性和内皮损伤之间的相关性仅在 SG 中发现。结论：ASM指数和强度的降低与微循环特征有关，表明微循环障碍可能在某种程度上参与了肌肉减少症的发展。炎症状态，尤其是升高的 IL-6，似乎在这一过程中发挥了重要作用。微血管功能和形态学结果未发现组间差异，但对数转换后的 IL-6 浓度在 SG 与 NSG 中高出两倍（P = 0.02）。ASM 指数、握力和膝关节等速力量与微循环功能标志物、毛细血管直径、血管反应性和内皮损伤之间的相关性仅在 SG 中发现。结论：ASM指数和强度的降低与微循环特征有关，表明微循环障碍可能在某种程度上参与了肌肉减少症的发展。炎症状态，尤其是升高的 IL-6，似乎在这一过程中发挥了重要作用。握力和膝关节等速力量与微循环功能、毛细血管直径、血管反应性和内皮损伤的标志物仅在 SG 中发现。结论：ASM指数和强度的降低与微循环特征有关，表明微循环障碍可能在某种程度上参与了肌肉减少症的发展。炎症状态，尤其是升高的 IL-6，似乎在这一过程中发挥了重要作用。握力和膝关节等速力量与微循环功能、毛细血管直径、血管反应性和内皮损伤的标志物仅在 SG 中发现。结论：ASM指数和强度的降低与微循环特征有关，表明微循环障碍可能在某种程度上参与了肌肉减少症的发展。炎症状态，尤其是升高的 IL-6，似乎在这一过程中发挥了重要作用。