Impulse control disorder is a prevalent side-effect of Parkinson’s disease (PD) medication, with a strong negative impact on the quality of life of those affected. Although impulsivity has classically been associated with response inhibition deficits, previous evidence from PD patients with impulse control disorder (ICD) has not revealed behavioral dysfunction in response inhibition. In this study, 18 PD patients with ICD, 17 PD patients without this complication, and 15 healthy controls performed a version of the conditional Stop Signal Task during functional magnetic resonance imaging. Whole-brain contrasts, regions of interest, and functional connectivity analyses were conducted. Our aim was to investigate the neural underpinnings of two aspects of response inhibition: proactive inhibition, inhibition that has been prepared beforehand, and restrained inhibition, inhibition of an invalid inhibitory tendency. We observed that, in respect to the other two groups, PD patients with ICD exhibited hyperactivation of the stopping network bilaterally while performing proactive inhibition. When engaged in restrained inhibition, they showed hyperactivation of the left inferior frontal gyrus, an area linked to action monitoring. Restrained inhibition also resulted in changes to the functional co-activation between inhibitory regions and left inferior parietal cortex and right supramarginal gyrus. Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.

冲动控制障碍是帕金森病 (PD) 药物的普遍副作用，对受影响者的生活质量具有强烈的负面影响。尽管冲动性通常与反应抑制缺陷有关，但先前来自患有冲动控制障碍 (ICD) 的 PD 患者的证据并未显示反应抑制中的行为功能障碍。在这项研究中，18 名患有 ICD 的 PD 患者、17 名没有这种并发症的 PD 患者和 15 名健康对照在功能性磁共振成像期间执行了条件停止信号任务的一个版本。进行了全脑对比、感兴趣区域和功能连接分析。我们的目的是研究反应抑制两个方面的神经基础：主动抑制，事先准备好的抑制和抑制抑制，抑制无效的抑制倾向。我们观察到，对于其他两组，患有 ICD 的 PD 患者在进行主动抑制的同时表现出双侧停止网络的过度激活。当进行抑制抑制时，他们表现出左侧额下回的过度激活，这是一个与动作监测相关的区域。抑制抑制还导致抑制区域与左下顶叶皮层和右缘上回之间的功能共激活发生变化。我们的研究结果表明，患有 ICD 的 PD 患者正确地完成了抑制任务，显示出抑制和注意区域的参与发生了改变。在主动抑制期间，他们表现出两个抑制区域的双侧过度激活，