Background

Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).

Methods

A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Serum humanin and thiobarbituric acid reactive substances (TBARS) were measured at the time of initial admission. The hospitalization data and MACE of all patients were collected.

Results

Circulating humanin levels were lower in the angina group compared to controls [124.22 ± 63.02 vs. 157.77 ± 99.93 pg/ml, p < 0.05] and even lower in MI patients [67.17 ± 24.35 pg/ml, p < 0.05 vs controls] and oxidative stress marker were higher in MI patients compared to the control and angina groups [12.94 ± 4.55 vs. 8.26 ± 1.66 vs. 9.06 ± 2.47 umol/ml, p < 0.05]. Lower circulating humanin levels was an independent risk factor of MI patients. Circulating humanin levels could be used to predict MACE in angina group.

Conclusions

Lower circulating humanin levels was an independent risk factor for CAD, and a potential prognostic marker for mild CAD.

General significance

Humanin may become a new index for the diagnosis and treatment of CAD.

中文翻译：

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循环中的humanin在冠状动脉疾病中较低，是人类主要心脏事件的预后生物标志物

背景

Humanin 是一种内源性线粒体衍生肽，在氧化应激、炎症和 CAD 中起关键作用。在这项研究中，我们测量了不稳定型心绞痛和心肌梗死患者的循环humanin、氧化应激和炎症标志物的水平，并研究了这些参数与主要不良心脏事件（MACE）之间的关系。

方法

共从吉林大学第一医院住院部招募327名受试者，根据临床资料和血管造影结果分为3组[对照组、心绞痛和心肌梗死（MI）]。在初次入院时测量血清humanin 和硫代巴比妥酸反应物质（TBARS）。收集所有患者的住院资料和MACE。

结果

与对照组相比，心绞痛组的循环humanin水平较低[124.22 ± 63.02 vs. 157.77 ± 99.93 pg/ml，p  < 0.05]，在 MI 患者中甚至更低[67.17 ± 24.35 pg/ml，p < 0.05 vs 对照组]和与对照组和心绞痛组相比，MI 患者的氧化应激标志物更高 [12.94 ± 4.55 vs. 8.26 ± 1.66 vs. 9.06 ± 2.47 umol/ml, p < 0.05]。较低的循环humanin水平是MI患者的独立危险因素。循环humanin水平可用于预测心绞痛组的MACE。

结论

较低的循环humanin水平是CAD的独立危险因素，也是轻度CAD的潜在预后标志物。

一般意义

Humanin可能成为CAD诊治的新指标。