The fascinating functions of proteins and peptides in biological systems have attracted intense interest to explore their mimics using polymers, including polypeptides synthesized from polymerization. The folding, structures and functions of proteins and polypeptides are largely dependent on their sequence. However, sequence-tunable polymerization for polypeptide synthesis is a long-lasting challenge. The application of polypeptides is also greatly hindered by their susceptibility to enzymatic degradation. Although poly-α/β-peptide has proven to be an effective strategy to address the stability issue, the synthesis of poly-α/β-peptide from polymerization is not available yet. Hereby, we demonstrate a living and controlled copolymerization on α-NCA and β-NTA to prepare sequence-tunable poly-α/β-peptides. This polymerization strategy shows a prominent solvent-driven characteristic, providing random-like copolymers of poly-α/β-peptides in THF and block-like copolymers of poly-α/β-peptides in a mixed solvent of CHCl₃/H₂O (95/5, v/v), and opens new avenues for sequence-tunable polymerization and enables facile synthesis of proteolysis tunable poly-α/β-peptides for diverse applications.

蛋白质和肽在生物系统中的迷人功能引起了人们的强烈兴趣，他们使用聚合物来探索它们的模拟物，包括聚合合成的多肽。蛋白质和多肽的折叠、结构和功能很大程度上取决于它们的序列。然而，用于多肽合成的序列可调聚合是一个长期的挑战。多肽对酶促降解的敏感性也极大地阻碍了它们的应用。尽管聚-α/β-肽已被证明是解决稳定性问题的有效策略，但聚合合成聚-α/β-肽尚不可用。因此，我们展示了在 α-NCA 和 β-NTA 上的活性和受控共聚，以制备序列可调的聚-α/β-肽。₃ /H ₂ O (95/5, v/v)，并为序列可调聚合开辟了新途径，并使蛋白水解可调聚-α/β-肽的轻松合成用于各种应用。