Cover Feature: Effect of Ectoine on the Conformation and Hybridization of dsDNA in Monolayer Films: A Spectroelectrochemical Study (ChemElectroChem 20/2021),ChemElectroChem

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Cover Feature: Effect of Ectoine on the Conformation and Hybridization of dsDNA in Monolayer Films: A Spectroelectrochemical Study (ChemElectroChem 20/2021)
ChemElectroChem ( IF 3.5 ) Pub Date : 2021-09-12 , DOI: 10.1002/celc.202101187
Julia Wittmar _{1,

2} , Corina Ohle _{3,

4} , Jörg Kunte ₃ , Izabella Brand ₁

Affiliation

The Cover Feature shows double strand DNA monolayers on the gold electrode surface stored for a long time in aqueous solutions in the absence and presence of ectoine, compatible solute. The use of polarization modulation infrared reflection absorption spectroscopy allowed to follow both the electric potential and time dependent changes in the conformation, orientation and hybridization state of DNA helices. Our results demonstrate that in monolayer films, the addition of compatible solutes, such as ectoine, to the electrolyte solution may have a protective effect on dsDNA stability over time. More information can be found in the Article by J. Wittmar et al.

中文翻译：

封面特征：四氢嘧啶对单层膜中 dsDNA 构象和杂交的影响：光谱电化学研究 (ChemElectroChem 20/2021)

Cover Feature显示金电极表面上的双链 DNA 单层在不存在和存在四氢嘧啶、相容溶质的情况下长时间储存在水溶液中。偏振调制红外反射吸收光谱的使用允许跟踪 DNA 螺旋的构象、取向和杂交状态的电位和时间依赖性变化。我们的结果表明，在单层膜中，向电解质溶液中添加相容的溶质，如四氢嘧啶，可能会对 dsDNA 的稳定性产生长期的保护作用。更多信息可以在 J. Wittmar 等人的文章中找到。

更新日期：2021-10-13

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