Efficient synthesis of piperidine derivatives using dendrimer based catalytical pockets,Journal of Heterocyclic Chemistry

当前位置： X-MOL 学术 › J. Heterocycl. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Efficient synthesis of piperidine derivatives using dendrimer based catalytical pockets
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2021-09-12 , DOI: 10.1002/jhet.4361
V. Unnikrishnan ₁ , G. Avudaiappan ₁ , Kiran James ₁ , A. Ajay ₁ , K. Sreekumar ₁

Affiliation

The synthesis of highly functionalized piperidine derivatives using amine functionalized maltitol-cored dendritic polymer (MAL-G0) in acetonitrile as the reaction medium is reported. A variety of piperidine derivatives were synthesized and the reaction gave an excellent yield of 89%–95%. The highly functionalized nature of the catalyst provided large number of active sites which resulted in good yield within a short period of time. Maltitol is a carbohydrate polyol system which was chosen here as the core for the synthesis of the dendritic catalyst; it was an effective approach for the preparation of piperidine like medicinal compounds. Maltitol-cored dendritic polymer was effectively synthesized and characterized using GPC, TG, UV–Visible, IR, and NMR techniques and also all the synthesized piperidine derivatives were characterized using LCMS, IR, and NMR techniques.

中文翻译：

使用基于树枝状聚合物的催化袋有效合成哌啶衍生物

报道了在乙腈中使用胺官能化麦芽糖醇为核心的树枝状聚合物 (MAL-G0) 作为反应介质合成高度官能化的哌啶衍生物。合成了多种哌啶衍生物，反应收率高达 89%~95%。催化剂的高度官能化性质提供了大量的活性位点，从而在短时间内获得了良好的收率。麦芽糖醇是一种碳水化合物多元醇系统，这里被选为合成树枝状催化剂的核心；是制备哌啶类药用化合物的有效途径。使用 GPC、TG、UV-Visible、IR 和 NMR 技术有效地合成和表征了麦芽糖醇核的树枝状聚合物，并且所有合成的哌啶衍生物均使用 LCMS、IR、

更新日期：2021-09-12

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11