Over the past decade, ROS-sensitive formulations have been widely used in atherosclerosis applications such as ROS scavenging, drug delivery, gene delivery, and imaging. The intensified interest in ROS-sensitive formulations is attributed to their unique self-adaptive properties, involving the main molecular mechanisms of solubility switch and degradation under the pathological ROS differences in atherosclerosis. This review outlines the advances in the use of ROS-sensitive formulations in atherosclerosis applications during the past decade, especially highlighting the general design requirements in relation to biomedical functional performance.

中文翻译：

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用于动脉粥样硬化应用的 ROS 敏感纳米制剂的最新进展


在过去的十年中，ROS敏感制剂已广泛应用于动脉粥样硬化应用，例如ROS清除、药物递送、基因递送和成像。人们对ROS敏感制剂的浓厚兴趣归因于其独特的自适应特性，涉及动脉粥样硬化病理性ROS差异下溶解度转换和降解的主要分子机制。本综述概述了过去十年在动脉粥样硬化应用中使用 ROS 敏感制剂的进展，特别强调了与生物医学功能性能相关的总体设计要求。