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Dry Powder Inhalers in the Digitalization Era: Current Status and Future Perspectives
Pharmaceutics ( IF 4.9 ) Pub Date : 2021-09-12 , DOI: 10.3390/pharmaceutics13091455
Styliani Xiroudaki 1 , Aurélie Schoubben 1 , Stefano Giovagnoli 1 , Dimitrios M Rekkas 2
Affiliation  

During the last decades, the term “drug delivery systems” (DDSs) has almost fully replaced previously used terms, such as “dosage forms”, in an attempt to emphasize the importance of the drug carrier in ensuring the claimed safety and effectiveness of the product. However, particularly in the case of delivery devices, the term “system”, which by definition implies a profound knowledge of each single part and their interactions, is not always fully justified when using the DDS term. Within this context, dry powder inhalers (DPIs), as systems to deliver drugs via inhalation to the lungs, require a deep understanding of the complex formulation–device–patient interplay. As of now and despite the progress made in particle engineering and devices design, DPIs’ clinical performance is limited by variable patients’ breathing patterns. To circumvent this pitfall, next-generation DPIs should ideally adapt to the different respiratory capacity of individuals across age, health conditions, and other related factors. In this context, the recent wave of digitalization in the health care and industrial sectors may drive DPI technology towards addressing a personalized device–formulation–patient liaison. In this review, evolving technologies are explored and analyzed to outline the progress made as well as the gaps to fill to align novel DPIs technologies with the systems theory approach.

中文翻译:

数字化时代的干粉吸入器:现状与未来展望

在过去的几十年里,“药物输送系统”(DDS)一词几乎完全取代了以前使用的术语,例如“剂型”,试图强调药物载体在确保所声称的安全性和有效性方面的重要性。产品。然而,特别是在输送设备的情况下,术语“系统”根据定义意味着对每个单独部件及其相互作用的深刻了解,在使用 DDS 术语时并不总是完全合理。在这种情况下,干粉吸入器 (DPI) 作为通过吸入将药物输送到肺部的系统,需要深入了解复杂的配方 - 设备 - 患者的相互作用。截至目前,尽管在粒子工程和设备设计方面取得了进展,但 DPI 的临床性能受到患者呼吸模式变化的限制。为了规避这个陷阱,下一代 DPI 应该理想地适应不同年龄、健康状况和其他相关因素的个体不同的呼吸能力。在这种情况下,最近医疗保健和工业部门的数字化浪潮可能会推动 DPI 技术解决个性化的设备-配方-患者联络问题。在这篇综述中,探索和分析了不断发展的技术,以概述取得的进展以及填补新 DPI 技术与系统理论方法之间的差距。最近医疗保健和工业部门的数字化浪潮可能会推动 DPI 技术解决个性化的设备-配方-患者联络问题。在这篇综述中,探索和分析了不断发展的技术,以概述取得的进展以及填补新 DPI 技术与系统理论方法之间的差距。最近医疗保健和工业部门的数字化浪潮可能会推动 DPI 技术解决个性化的设备-配方-患者联络问题。在这篇综述中,探索和分析了不断发展的技术,以概述取得的进展以及填补新 DPI 技术与系统理论方法之间的差距。
更新日期:2021-09-12
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