The unique microenvironment of solid tumors, including desmoplasia within the extracellular matrix, enhanced vascular permeability, and poor lymphatic drainage, leads to an elevated interstitial fluid pressure which is a major barrier to drug delivery. Reducing tumor interstitial fluid pressure is one proposed method of increasing drug delivery to the tumor. The goal of this topical review is to describe recent work using focused ultrasound with or without microbubbles to modulate tumor interstitial fluid pressure, through either thermal or mechanical effects on the extracellular matrix and the vasculature. Furthermore, we provide a review on techniques in which ultrasound imaging may be used to diagnose elevated interstitial fluid pressure within solid tumors. Ultrasound-based techniques show high promise in diagnosing and treating elevated interstitial pressure to enhance drug delivery.

中文翻译：

---

超声在调节实体瘤间质液压力以改善药物输送中的作用

实体瘤独特的微环境，包括细胞外基质内的结缔组织增生、血管通透性增强和淋巴引流不良，导致间质液压力升高，这是药物输送的主要障碍。降低肿瘤间质液压力是增加药物递送至肿瘤的一种建议方法。本专题综述的目的是描述最近使用聚焦超声（有或没有微泡）通过对细胞外基质和脉管系统的热效应或机械效应来调节肿瘤间质液压力的工作。此外，我们还回顾了超声成像可用于诊断实体瘤内升高的间质液压力的技术。